Multiorgan and Renal Tropism of SARS-CoV-2

In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions.

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Podrobná bibliografia
Vydané v:	The New England journal of medicine Ročník 383; číslo 6; s. 590 - 592
Hlavní autori:	Puelles, Victor G, Lütgehetmann, Marc, Lindenmeyer, Maja T, Sperhake, Jan P, Wong, Milagros N, Allweiss, Lena, Chilla, Silvia, Heinemann, Axel, Wanner, Nicola, Liu, Shuya, Braun, Fabian, Lu, Shun, Pfefferle, Susanne, Schröder, Ann S, Edler, Carolin, Gross, Oliver, Glatzel, Markus, Wichmann, Dominic, Wiech, Thorsten, Kluge, Stefan, Pueschel, Klaus, Aepfelbacher, Martin, Huber, Tobias B
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Massachusetts Medical Society 06.08.2020
Predmet:	Aged Aged, 80 and over Autopsy Betacoronavirus - isolation & purification Betacoronavirus - physiology Brain - virology Brain research Coronavirus Infections Coronaviruses Correspondence COVID-19 Female Heart - virology Humans Kidney - virology Kidneys Liver - virology Lung - virology Male Middle Aged Organotropism Pandemics Pharynx - virology Pneumonia, Viral Respiratory tract SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Tropism Viral Load Viral Tropism
ISSN:	0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:	In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions.
Bibliografia:	SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 14 ObjectType-Article-2 content type line 23 Drs. Puelles, Lütgehetmann, Lindenmeyer, and Sperhake contributed equally to this letter.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2011400