Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has rec...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Journal of nanobiotechnology Ročník 20; číslo 1; s. 279 - 29
Hlavní autori:	Zhang, Ying, Liu, Qiqi, Zhang, Xinmeng, Huang, Haoqiang, Tang, Shiqi, Chai, Yujuan, Xu, Zhourui, Li, Meirong, Chen, Xin, Liu, Jia, Yang, Chengbin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 14.06.2022 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Acids Analysis B cells Bioavailability Biocompatibility Biosynthesis Biotechnology Cancer Cancer therapies Cancer treatment Care and treatment Chemistry Chemistry and Materials Science Chemotherapy Circular RNA Clinical trials Delivery Deoxyribonucleic acid DNA Dosage and administration Drug development Drugs Efficiency Exosome Exosomes Extracellular vesicles Gene expression Gene therapy Genetic engineering Immunogenicity Lipids MicroRNA MicroRNAs miRNA Molecular Medicine mRNA Nanotechnology Nucleic acid drug Nucleic acids Proteins Public health Review Ribonucleic acid RNA siRNA Toxicity China Delivery Gene therapy Exosome Cancer treatment Nucleic acid drug
ISSN:	1477-3155, 1477-3155
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Abstract
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1477-3155 1477-3155
DOI:	10.1186/s12951-022-01472-z