Re-Examining the Association between Vitamin D and Childhood Caries

Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental...

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Published in:	PloS one Vol. 10; no. 12; p. e0143769
Main Authors:	Dudding, Tom, Thomas, Steve J., Duncan, Karen, Lawlor, Debbie A., Timpson, Nicholas J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 21.12.2015 Public Library of Science (PLoS)
Subjects:	25-Hydroxyvitamin D Age Analysis Child Child, Preschool Childhood Children Confidence intervals Data dictionaries Dental caries Dental Caries - blood Dental Caries - epidemiology Dental Caries - genetics Early experience England - epidemiology Epidemiology Female Follow-Up Studies Genetic diversity Genetic variance Genomes Humans Hydroxycholecalciferols - blood Male Mortality Parents & parenting Physiological aspects Randomization Risk factors Studies Surveys and Questionnaires Systematic review Teeth Vitamin D Vitamin deficiency England United Kingdom United Kingdom > UK
ISSN:	1932-6203, 1932-6203
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Abstract	Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses.
AbstractList	Background Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. Objective To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. Design A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. Results In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). Conclusions This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses. BackgroundPrevious studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear.ObjectiveTo determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic.DesignA Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months.ResultsIn multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72).ConclusionsThis Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses. Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses. Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses. Background Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. Objective To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. Design A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. Results In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). Conclusions This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses.
Audience	Academic
Author	Thomas, Steve J. Timpson, Nicholas J. Duncan, Karen Dudding, Tom Lawlor, Debbie A.
AuthorAffiliation	2 School of Oral and Dental Science, Bristol University, Bristol, United Kingdom 1 MRC Integrative Epidemiology Unit, School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom UNC School of Dentistry, University of North Carolina-Chapel Hill, UNITED STATES
AuthorAffiliation_xml	– name: 1 MRC Integrative Epidemiology Unit, School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom – name: 2 School of Oral and Dental Science, Bristol University, Bristol, United Kingdom – name: UNC School of Dentistry, University of North Carolina-Chapel Hill, UNITED STATES
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26692013$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1371/journal.pmed.1001383 10.1038/sj.bdj.2009.254 10.1136/bmj.2.3545.1079 10.4161/derm.15841 10.1111/j.1600-0528.2010.00548.x 10.4238/2015.September.28.15 10.1038/sj.bdj.4804690 10.1111/1467-985X.00130 10.1046/j.1365-3016.2001.00325.x 10.4161/derm.3.4.15027 10.1373/clinchem.2012.193185 10.1093/hmg/ddq155 10.1210/jc.2011-2516 10.1186/2046-4053-1-57 10.1016/j.acap.2009.09.010 10.1093/ije/dyt179 10.2217/fmb.09.87 10.1371/journal.pmed.0040352 10.1016/S0140-6736(12)62203-X 10.1093/biostatistics/kxq024 10.1136/bmj.g2035 10.1111/j.1753-4887.2012.00544.x 10.1002/sim.3034 10.1093/ije/dys064 10.1016/S0140-6736(10)60588-0 10.1038/sj.bdj.4800076 10.1186/1471-2458-14-206 10.2307/1912557
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: TD NJT. Performed the experiments: TD. Analyzed the data: TD. Wrote the paper: TD NJT SJT DAL. Collected data: KD.
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References	O Fejerskov (ref1) 2008; xxiii BL Edelstein (ref4) 2009; 9 DA Youssef (ref9) 2011; 3 HB Del Valle (ref28) QH Vuong (ref29) 1989; 57 DA Lawlor (ref27) 2013; 381 ref2 TJ Wang (ref19) 2010; 376 DA Lawlor (ref16) 2008; 27 AM Tolppanen (ref25) 2012; 97 DR Moles (ref5) 2009; 206 J Ahn (ref18) 2010; 19 A Boyd (ref22) 2013; 42 AF Gombart (ref8) 2009; 4 GD Smith (ref17) 2007; 4 KW Stephen (ref13) 1981; 151 E Theodoratou (ref14) 2014; 348 MJ Brion (ref32) 2013; 42 XP Hu (ref7) 2015; 14 EJ Kay (ref24) 2010; 38 J Golding (ref23) 2001; 15 D Bohning (ref30) 1999; 162 PS Clarke (ref31) 2010; 11 C Nobile (ref3) 2014; 14 AE Sharpenak (ref12) 1964; 23 KS Vimaleswaran (ref21) 2013; 10 WB Grant (ref10) 2011; 3 O Trummer (ref20) 2013; 59 CM Bridgman (ref6) 1999; 186 M Mellanby (ref11) 1928; 2 M Hooley (ref26) 2012; 1 PP Hujoel (ref15) 2013; 71
References_xml	– volume: 10 start-page: e1001383 issue: 2 year: 2013 ident: ref21 article-title: Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts publication-title: PLoS Med doi: 10.1371/journal.pmed.1001383 – volume: 206 start-page: E14 issue: 7 year: 2009 ident: ref5 article-title: Hospital admissions for dental care in children: England 1997–2006 publication-title: Br Dent J doi: 10.1038/sj.bdj.2009.254 – volume: 2 start-page: 1079 year: 1928 ident: ref11 article-title: The action of vitamin D in preventing the spread and promoting the arrest of caries in children publication-title: British Medical Journal doi: 10.1136/bmj.2.3545.1079 – volume: 3 start-page: 193 issue: 3 year: 2011 ident: ref10 article-title: A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries publication-title: Dermato-endocrinology doi: 10.4161/derm.15841 – volume: 38 start-page: 408 issue: 5 year: 2010 ident: ref24 article-title: Is there a relationship between birthweight and subsequent growth on the development of dental caries at 5 years of age? A cohort study publication-title: Community dentistry and oral epidemiology doi: 10.1111/j.1600-0528.2010.00548.x – volume: 14 start-page: 11631 issue: 3 year: 2015 ident: ref7 article-title: Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population publication-title: Genet Mol Res doi: 10.4238/2015.September.28.15 – volume: 151 start-page: 287 issue: 9 year: 1981 ident: ref13 article-title: A 4-year double-blind fluoridated school milk study in a vitamin-D deficient area publication-title: British Dental Journal doi: 10.1038/sj.bdj.4804690 – volume: 162 start-page: 195 issue: 2 year: 1999 ident: ref30 article-title: The Zero-Inflated Poisson Model and the Decayed, Missing and Filled Teeth Index in Dental Epidemiology publication-title: Journal of the Royal Statistical Society Series A (Statistics in Society) doi: 10.1111/1467-985X.00130 – volume: 15 start-page: 74 issue: 1 year: 2001 ident: ref23 article-title: ALSPAC—the Avon Longitudinal Study of Parents and Children. I. Study methodology publication-title: Paediatric and perinatal epidemiology doi: 10.1046/j.1365-3016.2001.00325.x – volume: 3 start-page: 220 issue: 4 year: 2011 ident: ref9 article-title: Antimicrobial implications of vitamin D publication-title: Dermato-Endocrinology doi: 10.4161/derm.3.4.15027 – volume: 59 start-page: 793 issue: 5 year: 2013 ident: ref20 article-title: Vitamin D and Mortality: A Mendelian Randomization Study publication-title: Clinical Chemistry doi: 10.1373/clinchem.2012.193185 – volume: 19 start-page: 2739 issue: 13 year: 2010 ident: ref18 article-title: Genome-wide association study of circulating vitamin D levels publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddq155 – volume: 97 start-page: 1202 issue: 4 year: 2012 ident: ref25 article-title: Risk factors for variation in 25-hydroxyvitamin D₃ and D₂ concentrations and vitamin D deficiency in children publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-2516 – volume: 1 start-page: 57- year: 2012 ident: ref26 article-title: Body mass index and dental caries in children and adolescents: a systematic review of literature published 2004 to 2011 publication-title: Systematic Reviews doi: 10.1186/2046-4053-1-57 – ident: ref28 article-title: Dietary reference intakes for calcium and vitamin D2011 publication-title: Dietary reference intakes for calcium and vitamin D2011 – volume: 9 start-page: 415 issue: 6 year: 2009 ident: ref4 article-title: Update on Disparities in Oral Health and Access to Dental Care for America's Children publication-title: Academic Pediatrics doi: 10.1016/j.acap.2009.09.010 – volume: 42 start-page: 1497 issue: 5 year: 2013 ident: ref32 article-title: Calculating statistical power in Mendelian randomization studies publication-title: Int J Epidemiol doi: 10.1093/ije/dyt179 – volume: xxiii start-page: 616 year: 2008 ident: ref1 article-title: Dental caries: the disease and its clinical management – volume: 4 start-page: 1151 issue: 9 year: 2009 ident: ref8 article-title: The vitamin D—antimicrobial peptide pathway and its role in protection against infection publication-title: Future Microbiology doi: 10.2217/fmb.09.87 – volume: 23 start-page: 423 year: 1964 ident: ref12 article-title: Role of Protein, Lysine, Certain Mineral Substances and Vitamins a and D in Prevention of Dental Caries publication-title: Federation Proceedings, Translation Supplement – volume: 4 start-page: e352 issue: 12 year: 2007 ident: ref17 article-title: Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology publication-title: PLoS Med doi: 10.1371/journal.pmed.0040352 – ident: ref2 – volume: 381 start-page: 2176 issue: 9884 year: 2013 ident: ref27 article-title: Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study publication-title: Lancet doi: 10.1016/S0140-6736(12)62203-X – volume: 11 start-page: 756 issue: 4 year: 2010 ident: ref31 article-title: Identification of causal effects on binary outcomes using structural mean models publication-title: Biostatistics doi: 10.1093/biostatistics/kxq024 – volume: 348 start-page: g2035 year: 2014 ident: ref14 article-title: Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials publication-title: Bmj doi: 10.1136/bmj.g2035 – volume: 71 start-page: 88 issue: 2 year: 2013 ident: ref15 article-title: Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis publication-title: Nutrition Reviews doi: 10.1111/j.1753-4887.2012.00544.x – volume: 27 start-page: 1133 issue: 8 year: 2008 ident: ref16 article-title: Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology publication-title: Stat Med doi: 10.1002/sim.3034 – volume: 42 start-page: 111 issue: 1 year: 2013 ident: ref22 article-title: Cohort Profile: the 'children of the 90s'—the index offspring of the Avon Longitudinal Study of Parents and Children publication-title: Int J Epidemiol doi: 10.1093/ije/dys064 – volume: 376 start-page: 180 issue: 9736 year: 2010 ident: ref19 article-title: Common genetic determinants of vitamin D insufficiency: a genome-wide association study publication-title: Lancet doi: 10.1016/S0140-6736(10)60588-0 – volume: 186 start-page: 245 issue: 5 year: 1999 ident: ref6 article-title: paediatric dentistry: An investigation of the effects on children of tooth extraction under general anaesthesia in general dental practice publication-title: Br Dent J doi: 10.1038/sj.bdj.4800076 – volume: 14 start-page: 206 issue: 1 year: 2014 ident: ref3 article-title: Pattern and severity of early childhood caries in Southern Italy: a preschool-based cross-sectional study publication-title: BMC Public Health doi: 10.1186/1471-2458-14-206 – volume: 57 start-page: 307 issue: 2 year: 1989 ident: ref29 article-title: Likelihood Ratio Tests for Model Selection and Non-Nested Hypotheses publication-title: Econometrica doi: 10.2307/1912557
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Snippet	Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the... Background Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear.... Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the... BACKGROUNDPrevious studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is... BackgroundPrevious studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is... Background Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear....
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SubjectTerms	25-Hydroxyvitamin D Age Analysis Child Child, Preschool Childhood Children Confidence intervals Data dictionaries Dental caries Dental Caries - blood Dental Caries - epidemiology Dental Caries - genetics Early experience England - epidemiology Epidemiology Female Follow-Up Studies Genetic diversity Genetic variance Genomes Humans Hydroxycholecalciferols - blood Male Mortality Parents & parenting Physiological aspects Randomization Risk factors Studies Surveys and Questionnaires Systematic review Teeth Vitamin D Vitamin deficiency
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Title	Re-Examining the Association between Vitamin D and Childhood Caries
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