Re-Examining the Association between Vitamin D and Childhood Caries

Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental...

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Veröffentlicht in:PloS one Jg. 10; H. 12; S. e0143769
Hauptverfasser: Dudding, Tom, Thomas, Steve J., Duncan, Karen, Lawlor, Debbie A., Timpson, Nicholas J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 21.12.2015
Public Library of Science (PLoS)
Schlagworte:
25-Hydroxyvitamin D
Age
Analysis
Child
Child, Preschool
Childhood
Children
Confidence intervals
Data dictionaries
Dental caries
Dental Caries - blood
Dental Caries - epidemiology
Dental Caries - genetics
Early experience
England - epidemiology
Epidemiology
Female
Follow-Up Studies
Genetic diversity
Genetic variance
Genomes
Humans
Hydroxycholecalciferols - blood
Male
Mortality
Parents & parenting
Physiological aspects
Randomization
Risk factors
Studies
Surveys and Questionnaires
Systematic review
Teeth
Vitamin D
Vitamin deficiency
England
United Kingdom
United Kingdom > UK
ISSN:1932-6203, 1932-6203
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Zusammenfassung:Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic. A Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months. In multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72). This Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses.
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: TD NJT. Performed the experiments: TD. Analyzed the data: TD. Wrote the paper: TD NJT SJT DAL. Collected data: KD.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0143769