Polymorphisms of Immunity Genes and Susceptibility to Otitis Media in Children

Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for th...

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Bibliographic Details
Published in:PloS one Vol. 9; no. 4; p. e93930
Main Authors: Nokso-Koivisto, Johanna, Chonmaitree, Tasnee, Jennings, Kristofer, Matalon, Reuben, Block, Stan, Patel, Janak A.
Format: Journal Article
Language:English
Published: United States Public Library of Science 01.04.2014
Public Library of Science (PLoS)
Subjects:
Adaptive immunity
Adaptive Immunity - genetics
Age
Alleles
Analysis
Biology and Life Sciences
Breastfeeding & lactation
Care and treatment
Chemokines
Child
Child, Preschool
Children
CX3C Chemokine Receptor 1
CX3CR1 protein
Cytokines
Data processing
Development and progression
Disease susceptibility
Ear diseases
Environmental factors
Female
Follow-Up Studies
Gene Frequency
Generalized linear models
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetics
Genotype
Health risks
Humans
Immunity
Immunity, Innate - genetics
Infant
Infections
Infectious diseases
Interleukin 10
Interleukin 5
Interleukin 8
Interleukins - genetics
Interleukins - physiology
Male
Medicine and Health Sciences
Otitis media
Otitis Media - epidemiology
Otitis Media - genetics
Otitis Media - immunology
Otolaryngology
Pediatrics
Polymorphism, Single Nucleotide
Prospective Studies
Receptors, Chemokine - genetics
Receptors, Chemokine - physiology
Respiratory syncytial virus
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - genetics
Respiratory Tract Infections - immunology
Retrospective Studies
Risk
Risk factors
Single-nucleotide polymorphism
Studies
Vaccines
Viral infections
Virus Diseases - genetics
Virus Diseases - immunology
Texas
Kentucky
United States > US
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Summary:Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for their role in OM. Using Sequenom Massarray platform, 21 SNPs were studied in 653 children from prospective (n = 202) and retrospective (n = 451) cohorts. Data were analyzed for the relationship between SNPs and upper respiratory infection (URI) frequency, risk of acute OM during URI episodes, and proneness to recurrent OM. Increased risk for OM proneness was associated with CX3CR1 (Thr280Met) SNP and with a jointly interactive group of IL-10 (-1082) SNP, IL-1β (-511) wild type genotype and white race. Family history of OM proneness independently increased the risk for frequent URIs, OM occurrence during URI, and OM proneness. Additionally, IL-1β (-31) SNP was associated with increased risk for frequent URIs, but IL-10 (-592), IL-1β (-511), IL-5 (-746) and IL-8 (-251) SNPs were associated with decreased risk of URI. IL-1β (-31), CX3CR1 (Thr280Met), IL-10 (-1082) and IL-1β (-511) SNPs were associated with increased risk for frequent URIs or OM proneness.
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Conceived and designed the experiments: JN TC KJ RM SB JAP. Performed the experiments: JN TC. Analyzed the data: JN TC KJ RM JAP. Contributed reagents/materials/analysis tools: KJ SB. Wrote the paper: JN TC KJ RM SB JAP.
Current address: Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
Competing Interests: The authors have the following interests: Dr. Stan Block is an employee of Kentucky Pediatric Research, Inc, Bardstown, Kentucky, which is a commercial company. This does not alter the authors′ adherence to PLOS One policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0093930