Polymorphisms of Immunity Genes and Susceptibility to Otitis Media in Children

Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for th...

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Vydané v:	PloS one Ročník 9; číslo 4; s. e93930
Hlavní autori:	Nokso-Koivisto, Johanna, Chonmaitree, Tasnee, Jennings, Kristofer, Matalon, Reuben, Block, Stan, Patel, Janak A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.04.2014 Public Library of Science (PLoS)
Predmet:	Adaptive immunity Adaptive Immunity - genetics Age Alleles Analysis Biology and Life Sciences Breastfeeding & lactation Care and treatment Chemokines Child Child, Preschool Children CX3C Chemokine Receptor 1 CX3CR1 protein Cytokines Data processing Development and progression Disease susceptibility Ear diseases Environmental factors Female Follow-Up Studies Gene Frequency Generalized linear models Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genetics Genotype Health risks Humans Immunity Immunity, Innate - genetics Infant Infections Infectious diseases Interleukin 10 Interleukin 5 Interleukin 8 Interleukins - genetics Interleukins - physiology Male Medicine and Health Sciences Otitis media Otitis Media - epidemiology Otitis Media - genetics Otitis Media - immunology Otolaryngology Pediatrics Polymorphism, Single Nucleotide Prospective Studies Receptors, Chemokine - genetics Receptors, Chemokine - physiology Respiratory syncytial virus Respiratory Tract Infections - epidemiology Respiratory Tract Infections - genetics Respiratory Tract Infections - immunology Retrospective Studies Risk Risk factors Single-nucleotide polymorphism Studies Vaccines Viral infections Virus Diseases - genetics Virus Diseases - immunology Texas Kentucky United States > US
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for their role in OM. Using Sequenom Massarray platform, 21 SNPs were studied in 653 children from prospective (n = 202) and retrospective (n = 451) cohorts. Data were analyzed for the relationship between SNPs and upper respiratory infection (URI) frequency, risk of acute OM during URI episodes, and proneness to recurrent OM. Increased risk for OM proneness was associated with CX3CR1 (Thr280Met) SNP and with a jointly interactive group of IL-10 (-1082) SNP, IL-1β (-511) wild type genotype and white race. Family history of OM proneness independently increased the risk for frequent URIs, OM occurrence during URI, and OM proneness. Additionally, IL-1β (-31) SNP was associated with increased risk for frequent URIs, but IL-10 (-592), IL-1β (-511), IL-5 (-746) and IL-8 (-251) SNPs were associated with decreased risk of URI. IL-1β (-31), CX3CR1 (Thr280Met), IL-10 (-1082) and IL-1β (-511) SNPs were associated with increased risk for frequent URIs or OM proneness.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: JN TC KJ RM SB JAP. Performed the experiments: JN TC. Analyzed the data: JN TC KJ RM JAP. Contributed reagents/materials/analysis tools: KJ SB. Wrote the paper: JN TC KJ RM SB JAP. Current address: Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland Competing Interests: The authors have the following interests: Dr. Stan Block is an employee of Kentucky Pediatric Research, Inc, Bardstown, Kentucky, which is a commercial company. This does not alter the authors′ adherence to PLOS One policies on sharing data and materials.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0093930