RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR axis, although treatment resistance is a major problem. Here, we aimed to understand how RCC cells acquire resistance to PI3K-mTOR inhibition. We...

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Bibliographic Details
Published in:	PloS one Vol. 13; no. 2; p. e0191890
Main Authors:	Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L., Protheroe, Andrew S., Macaulay, Valentine M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2018 Public Library of Science (PLoS)
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Allosteric properties Analysis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzamides Biology and Life Sciences Cancer Cancer cells Cancer therapies Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell culture Cell Line, Tumor Clinical trials Continuous culture Drug dosages Drug resistance Drug Resistance, Neoplasm Enzyme inhibitors Experiments Extracellular signal-regulated kinase Gene expression Genetic aspects Genetic regulation Hematology Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humans Imidazoles - pharmacology Imidazoles - therapeutic use Inhibition Inhibitors Insulin-like growth factors Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Medicine and Health Sciences Metastasis Morpholines - therapeutic use mRNA Mutation Oncology Passengers Pharmacodynamics Pharmacology Phosphoinositide-3 Kinase Inhibitors Phosphorylation Proteins Pyrimidines Quinolines - pharmacology Quinolines - therapeutic use Rapamycin Regulatory-Associated Protein of mTOR - metabolism Renal cell carcinoma Research and Analysis Methods Signal Transduction - drug effects TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors Treatment resistance Up-Regulation United Kingdom > UK
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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