The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus (EBV), vitamin D,...

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Bibliographic Details
Published in:	Neural regeneration research Vol. 14; no. 3; pp. 373 - 386
Main Authors:	Guan, Yi, Jakimovski, Dejan, Ramanathan, Murali, Weinstock-Guttman, Bianca, Zivadinov, Robert
Format:	Journal Article
Language:	English
Published:	India Wolters Kluwer India Pvt. Ltd 01.03.2019 Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA%Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA%Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA%Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications
Subjects:	Antigen presentation B cells Blood-brain barrier Brain Central nervous system Cytotoxicity Diagnosis Disease control Disease prevention Epstein-Barr virus Epstein-Barr virus; multiple sclerosis; meningeal inflammation; magnetic resonance imaging; leptomeningeal contrast enhancement; mononucleosis; human endogeneous retrovirus-W; B-cells Gene expression Genetic aspects Hypotheses Immunoglobulins Infections Infectious mononucleosis Inflammation Monoclonal antibodies Mononucleosis Multiple sclerosis Nervous system Neurons Pathogenesis Permeability Review Viruses Vitamin D Vitamins B-cells magnetic resonance imaging meningeal inflammation leptomeningeal contrast enhancement human endogeneous retrovirus-W mononucleosis multiple sclerosis Epstein-Barr virus
ISSN:	1673-5374, 1876-7958
Online Access:	Get full text
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