The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Me...

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Vydané v:	BMC infectious diseases Ročník 21; číslo 1; s. 157 - 9
Hlavní autori:	Canovi, Simone, Besutti, Giulia, Bonelli, Efrem, Iotti, Valentina, Ottone, Marta, Albertazzi, Laura, Zerbini, Alessandro, Pattacini, Pierpaolo, Giorgi Rossi, Paolo, Colla, Rossana, Fasano, Tommaso
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 08.02.2021 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Adult Automation Blood pressure Blood tests C-reactive protein C-Reactive Protein - metabolism Chest Clinical laboratory Computed tomography Coronaviruses COVID-19 COVID-19 - blood COVID-19 - diagnosis COVID-19 - physiopathology Creatinine Cross-Sectional Studies CT imaging Emergency medical care Emergency medical services Female Gas exchange Health surveillance Hospitalization Hospitals Humans Infectious Diseases Inflammation Inflammatory response Internal Medicine Italy Laboratory tests Lesions Leukocytes Leukocytes (neutrophilic) Lung - diagnostic imaging Lung - pathology Lungs Lymphocyte Count Lymphocytes Male Medical imaging Medical laboratories Medical Microbiology Medicine Medicine & Public Health Middle Aged Oxygen Oxygen - blood Oxygen content Pandemics Parasitology Partial pressure Pathogenesis Patients Platelets Procalcitonin Procalcitonin - blood Prognosis Pulmonary lesions Research Article Retrospective Studies Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Software Statistics Tomography, X-Ray Computed Tropical Medicine Viral diseases Italy United States > US COVID-19 Computed tomography Clinical laboratory
ISSN:	1471-2334, 1471-2334
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Shrnutí:	Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-021-05855-9