The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Me...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BMC infectious diseases Jg. 21; H. 1; S. 157 - 9
Hauptverfasser: Canovi, Simone, Besutti, Giulia, Bonelli, Efrem, Iotti, Valentina, Ottone, Marta, Albertazzi, Laura, Zerbini, Alessandro, Pattacini, Pierpaolo, Giorgi Rossi, Paolo, Colla, Rossana, Fasano, Tommaso
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 08.02.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Adult
Automation
Blood pressure
Blood tests
C-reactive protein
C-Reactive Protein - metabolism
Chest
Clinical laboratory
Computed tomography
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - physiopathology
Creatinine
Cross-Sectional Studies
CT imaging
Emergency medical care
Emergency medical services
Female
Gas exchange
Health surveillance
Hospitalization
Hospitals
Humans
Infectious Diseases
Inflammation
Inflammatory response
Internal Medicine
Italy
Laboratory tests
Lesions
Leukocytes
Leukocytes (neutrophilic)
Lung - diagnostic imaging
Lung - pathology
Lungs
Lymphocyte Count
Lymphocytes
Male
Medical imaging
Medical laboratories
Medical Microbiology
Medicine
Medicine & Public Health
Middle Aged
Oxygen
Oxygen - blood
Oxygen content
Pandemics
Parasitology
Partial pressure
Pathogenesis
Patients
Platelets
Procalcitonin
Procalcitonin - blood
Prognosis
Pulmonary lesions
Research Article
Retrospective Studies
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Software
Statistics
Tomography, X-Ray Computed
Tropical Medicine
Viral diseases
Italy
United States > US
COVID-19
Computed tomography
Clinical laboratory
ISSN:1471-2334, 1471-2334
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Undefined-3
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-021-05855-9