Potential viral pathogenic mechanism in human type 1 diabetes

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-pro...

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Bibliographic Details
Published in:	Diabetologia Vol. 57; no. 10; pp. 2009 - 2018
Main Authors:	Schneider, Darius A., von Herrath, Matthias G.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2014 Springer Springer Nature B.V
Subjects:	Antigens Autoimmunity - immunology Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Diabetes Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology Humans Inflammation Internal Medicine Lymphocytes Medical sciences Medicine Medicine & Public Health Metabolic Diseases Pancreas Pathogenesis Review Viral infections Virus Diseases - complications Virus Diseases - immunology La Jolla California United States > US Insulitis Type 1 diabetes Humans Viruses Autoimmune Enterovirus Environmental factors Endocrinopathy Autoimmunity Human Immunopathology Picornaviridae Autoimmune disease Environmental factor Virus
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
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