Potential viral pathogenic mechanism in human type 1 diabetes

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-pro...

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Vydáno v:	Diabetologia Ročník 57; číslo 10; s. 2009 - 2018
Hlavní autoři:	Schneider, Darius A., von Herrath, Matthias G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2014 Springer Springer Nature B.V
Témata:	Antigens Autoimmunity - immunology Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Diabetes Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology Humans Inflammation Internal Medicine Lymphocytes Medical sciences Medicine Medicine & Public Health Metabolic Diseases Pancreas Pathogenesis Review Viral infections Virus Diseases - complications Virus Diseases - immunology La Jolla California United States > US Insulitis Type 1 diabetes Humans Viruses Autoimmune Enterovirus Environmental factors Endocrinopathy Autoimmunity Human Immunopathology Picornaviridae Autoimmune disease Environmental factor Virus
ISSN:	0012-186X, 1432-0428, 1432-0428
On-line přístup:	Získat plný text
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Popis
Shrnutí:	In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0012-186X 1432-0428 1432-0428
DOI:	10.1007/s00125-014-3340-7