Translocation and dissemination of commensal bacteria in post-stroke infection

In humans and rodent models, commensal gut bacteria contribute to post-stroke infection. Experimental stroke in rodents causes gut barrier dysfunction and permeability, enabling translocation and dissemination of host gut microbiota. Bacterial infection is highly prevalent in patients who have had a...

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Bibliographic Details
Published in:	Nature medicine Vol. 22; no. 11; pp. 1277 - 1284
Main Authors:	Stanley, Dragana, Mason, Linda J, Mackin, Kate E, Srikhanta, Yogitha N, Lyras, Dena, Prakash, Monica D, Nurgali, Kulmira, Venegas, Andres, Hill, Michael D, Moore, Robert J, Wong, Connie H Y
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2016 Nature Publishing Group
Subjects:	631/250/371 631/326/2565/2134 64/60 692/617/375/534 Adrenergic beta-Antagonists - pharmacology Aged Aged, 80 and over Animals Bacteremia - immunology Bacteremia - metabolism Bacteremia - microbiology Bacteria Bacterial diseases Bacterial infections Bacterial Infections - immunology Bacterial Infections - metabolism Bacterial Infections - microbiology Bacterial Translocation - immunology Bioinformatics Biomedicine Blood Culture Cancer Research Computational Biology Disease Models, Animal Enterococcus faecalis Female Gastrointestinal Microbiome - genetics Genetic aspects Goblet Cells - cytology Goblet Cells - metabolism Gram-Positive Bacterial Infections - immunology Gram-Positive Bacterial Infections - metabolism Gram-Positive Bacterial Infections - microbiology High-Throughput Nucleotide Sequencing Humans Identification and classification Infarction, Middle Cerebral Artery - immunology Infectious Diseases Intestine, Small - cytology Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - microbiology Male Metabolic Diseases Mice Microbiota - genetics Microorganisms Middle Aged Molecular Medicine Neurosciences Pathogenic bacteria Pathogens Permeability Permeability - drug effects Physiological aspects Pneumonia Pneumonia, Bacterial - immunology Pneumonia, Bacterial - metabolism Pneumonia, Bacterial - microbiology Receptors, Adrenergic, beta - metabolism Ribosomal RNA RNA, Ribosomal, 16S - genetics Sequence Analysis, RNA Specific Pathogen-Free Organisms Stroke Stroke - immunology Translocation Urinary Tract Infections - immunology Urinary Tract Infections - metabolism Urinary Tract Infections - microbiology Virulence (Microbiology) Zonula Occludens-1 Protein - metabolism
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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