The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers

Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathoge...

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Vydané v:	PLoS neglected tropical diseases Ročník 8; číslo 6; s. e2858
Hlavní autori:	Zapata, Juan C., Cox, Dermot, Salvato, Maria S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.06.2014 Public Library of Science (PLoS)
Predmet:	Arenaviridae Bacteria, Pathogenic Biology and Life Sciences Blood platelets Blood Platelets - physiology Bunyaviridae Causes of Complications and side effects Dengue fever Disease Ebola virus Epidemiology Fatalities Filoviridae Flaviviridae Hemophilia Hemorrhagic fever Hemorrhagic Fevers, Viral - physiopathology Host-Pathogen Interactions Humans Insect bites Mammals Medicine and Health Sciences Pathogenesis Physiological aspects Proteins Review RNA Viruses - physiology Tropical diseases Viruses Zoonoses
ISSN:	1935-2735, 1935-2727, 1935-2735
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Popis
Shrnutí:	Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 The authors have declared that no competing interests exist.
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0002858