The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers

Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathoge...

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Bibliographic Details
Published in:PLoS neglected tropical diseases Vol. 8; no. 6; p. e2858
Main Authors: Zapata, Juan C., Cox, Dermot, Salvato, Maria S.
Format: Journal Article
Language:English
Published: United States Public Library of Science 01.06.2014
Public Library of Science (PLoS)
Subjects:
Arenaviridae
Bacteria, Pathogenic
Biology and Life Sciences
Blood platelets
Blood Platelets - physiology
Bunyaviridae
Causes of
Complications and side effects
Dengue fever
Disease
Ebola virus
Epidemiology
Fatalities
Filoviridae
Flaviviridae
Hemophilia
Hemorrhagic fever
Hemorrhagic Fevers, Viral - physiopathology
Host-Pathogen Interactions
Humans
Insect bites
Mammals
Medicine and Health Sciences
Pathogenesis
Physiological aspects
Proteins
Review
RNA Viruses - physiology
Tropical diseases
Viruses
Zoonoses
ISSN:1935-2735, 1935-2727, 1935-2735
Online Access:Get full text
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Description
Summary:Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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The authors have declared that no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002858