Sublingual immunotherapy not effective in house dust mite-allergic children in primary care

To cite this article: de Bot CMA, Moed H, Berger MY, Röder E, Hop WCJ, de Groot H, de Jongste JC, van Wijk RG, Bindels PJE, van der Wouden JC. Sublingual immunotherapy not effective in house dust mite–allergic children in primary care. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.0121...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Pediatric allergy and immunology Ročník 23; číslo 2; s. 151 - 159
Hlavní autoři:	de Bot, Cindy M. A., Moed, Heleen, Berger, Marjolein Y., Röder, Esther, Hop, Wim C. J., de Groot, Hans, de Jongste, Johan C., Gerth van Wijk, Roy, Bindels, Patrick J. E., van der Wouden, Johannes C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.03.2012 Blackwell Wiley Subscription Services, Inc
Témata:	Administration, Sublingual Adolescent Allergens Allergic rhinitis Animals Antigens, Dermatophagoides - administration & dosage Biological and medical sciences Child Children Dermatophagoides pteronyssinus Desensitization, Immunologic - methods Double-Blind Method Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects house dust mite Humans Hypersensitivity - prevention & control Immunotherapy Male Medical sciences Non tumoral diseases Nose Oral administration Otorhinolaryngology. Stomatology primary care Pyroglyphidae - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis sublingual Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Human Allergy Immunopathology Pediatrics Nose disease Desensitization Rhinitis house dust mite Primary health care House dust Sublingual administration Mite Immunology Treatment Efficiency Immunotherapy Adolescent ENT disease primary care allergic rhinitis Sublingual Child
ISSN:	0905-6157, 1399-3038, 1399-3038
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	To cite this article: de Bot CMA, Moed H, Berger MY, Röder E, Hop WCJ, de Groot H, de Jongste JC, van Wijk RG, Bindels PJE, van der Wouden JC. Sublingual immunotherapy not effective in house dust mite–allergic children in primary care. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.01219.x Background: Sublingual immunotherapy (SLIT) as a therapy for the treatment of allergic rhinitis in children might be acceptable as an alternative for subcutaneous immunotherapy. However, the efficacy of SLIT with house dust mite extract is not well established. Objective: To investigate whether SLIT in house dust mite–allergic children recruited in primary care is effective and safe. Methods: Children aged 6–18 years (n = 251) recruited in primary care with a house dust mite–induced allergic rhinitis received either SLIT or placebo for 2 years. Symptoms and medication use were assessed throughout the study. Primary outcome parameter was the mean total nose symptom score (scales 0–12) during the autumn of the second treatment year. Safety was assessed by recording any adverse event. Results: Overall, the mean nose symptom score ± s.d. after 2 years of treatment showed no significant effect of SLIT (symptom score intervention group 2.26 ± 1.84 vs. placebo group, 2.02 ± 1.67; p = 0.08). There were no significant differences in secondary outcomes, nor in subgroup analyses. The number of patients reporting adverse events was comparable between both groups. Conclusions: Sublingual immunotherapy with house dust mite allergen was not better than placebo in reducing rhinitis symptoms in house dust mite–allergic children in primary care. SLIT as administered in this study can be considered safe.
Bibliografie:	ArticleID:PAI1219 istex:DCCF1B0D51B31CB22FF12FC3653489D6DC3DF020 ark:/67375/WNG-DBQ01GG3-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0905-6157 1399-3038 1399-3038
DOI:	10.1111/j.1399-3038.2011.01219.x