Sublingual immunotherapy not effective in house dust mite-allergic children in primary care

To cite this article: de Bot CMA, Moed H, Berger MY, Röder E, Hop WCJ, de Groot H, de Jongste JC, van Wijk RG, Bindels PJE, van der Wouden JC. Sublingual immunotherapy not effective in house dust mite–allergic children in primary care. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.0121...

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Published in:Pediatric allergy and immunology Vol. 23; no. 2; pp. 151 - 159
Main Authors: de Bot, Cindy M. A., Moed, Heleen, Berger, Marjolein Y., Röder, Esther, Hop, Wim C. J., de Groot, Hans, de Jongste, Johan C., Gerth van Wijk, Roy, Bindels, Patrick J. E., van der Wouden, Johannes C.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01.03.2012
Blackwell
Wiley Subscription Services, Inc
Subjects:
Administration, Sublingual
Adolescent
Allergens
Allergic rhinitis
Animals
Antigens, Dermatophagoides - administration & dosage
Biological and medical sciences
Child
Children
Dermatophagoides pteronyssinus
Desensitization, Immunologic - methods
Double-Blind Method
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
house dust mite
Humans
Hypersensitivity - prevention & control
Immunotherapy
Male
Medical sciences
Non tumoral diseases
Nose
Oral administration
Otorhinolaryngology. Stomatology
primary care
Pyroglyphidae - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
sublingual
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Human
Allergy
Immunopathology
Pediatrics
Nose disease
Desensitization
Rhinitis
house dust mite
Primary health care
House dust
Sublingual administration
Mite
Immunology
Treatment
Efficiency
Immunotherapy
Adolescent
ENT disease
primary care
allergic rhinitis
Sublingual
Child
ISSN:0905-6157, 1399-3038, 1399-3038
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Summary:To cite this article: de Bot CMA, Moed H, Berger MY, Röder E, Hop WCJ, de Groot H, de Jongste JC, van Wijk RG, Bindels PJE, van der Wouden JC. Sublingual immunotherapy not effective in house dust mite–allergic children in primary care. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.01219.x Background:  Sublingual immunotherapy (SLIT) as a therapy for the treatment of allergic rhinitis in children might be acceptable as an alternative for subcutaneous immunotherapy. However, the efficacy of SLIT with house dust mite extract is not well established. Objective:  To investigate whether SLIT in house dust mite–allergic children recruited in primary care is effective and safe. Methods:  Children aged 6–18 years (n = 251) recruited in primary care with a house dust mite–induced allergic rhinitis received either SLIT or placebo for 2 years. Symptoms and medication use were assessed throughout the study. Primary outcome parameter was the mean total nose symptom score (scales 0–12) during the autumn of the second treatment year. Safety was assessed by recording any adverse event. Results:  Overall, the mean nose symptom score ± s.d. after 2 years of treatment showed no significant effect of SLIT (symptom score intervention group 2.26 ± 1.84 vs. placebo group, 2.02 ± 1.67; p = 0.08). There were no significant differences in secondary outcomes, nor in subgroup analyses. The number of patients reporting adverse events was comparable between both groups. Conclusions:  Sublingual immunotherapy with house dust mite allergen was not better than placebo in reducing rhinitis symptoms in house dust mite–allergic children in primary care. SLIT as administered in this study can be considered safe.
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ISSN:0905-6157
1399-3038
1399-3038
DOI:10.1111/j.1399-3038.2011.01219.x