Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats

Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term potentiation (LTP). Since LTP is a form of synaptic plasticity thought to be involved in learning and memory,...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 90; no. 19; p. 9191
Main Authors:	Böhme, G A, Bon, C, Lemaire, M, Reibaud, M, Piot, O, Stutzmann, J M, Doble, A, Blanchard, J C
Format:	Journal Article
Language:	English
Published:	United States 01.10.1993
Subjects:	Amino Acid Oxidoreductases - antagonists & inhibitors Animals Arginine - analogs & derivatives Arginine - pharmacology Avoidance Learning - drug effects Hippocampus - drug effects Hippocampus - enzymology Hippocampus - physiology In Vitro Techniques Learning - drug effects Male Memory - drug effects Memory - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Nitric Oxide Synthase Nitroarginine Rats Rats, Sprague-Dawley Rats, Wistar Smell Social Behavior Space Perception Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Time Factors
ISSN:	0027-8424
Online Access:	Get more information
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