Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats

Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term potentiation (LTP). Since LTP is a form of synaptic plasticity thought to be involved in learning and memory,...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 90; číslo 19; s. 9191
Hlavní autori:	Böhme, G A, Bon, C, Lemaire, M, Reibaud, M, Piot, O, Stutzmann, J M, Doble, A, Blanchard, J C
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.10.1993
Predmet:	Amino Acid Oxidoreductases - antagonists & inhibitors Animals Arginine - analogs & derivatives Arginine - pharmacology Avoidance Learning - drug effects Hippocampus - drug effects Hippocampus - enzymology Hippocampus - physiology In Vitro Techniques Learning - drug effects Male Memory - drug effects Memory - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Nitric Oxide Synthase Nitroarginine Rats Rats, Sprague-Dawley Rats, Wistar Smell Social Behavior Space Perception Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Time Factors
ISSN:	0027-8424
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Popis
Shrnutí:	Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-term potentiation (LTP). Since LTP is a form of synaptic plasticity thought to be involved in learning and memory, we have tested whether inhibition of endogenous NO production affects memory capacities of rats. We found that the NO synthase [L-arginine, NADPH:oxygen oxidoreductase (nitric oxide-forming), EC 1.14.13.39] inhibitor N omega-nitro-L-arginine, at doses blocking LTP in hippocampal slices, impairs spatial learning in a radial arm maze and olfactory memory in a social recognition test. In contrast, N omega-nitro-L-arginine left shock-avoidance learning unaffected. These results indicate that NO is involved in some but not all forms of memory and further support the existence of a causal link between LTP and spatial learning.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0027-8424
DOI:	10.1073/pnas.90.19.9191