Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

Fish oils (FOs) have anti-inflammatory effects and lower serum triglycerides. This study examined adipose and muscle inflammatory markers after treatment of humans with FOs and measured the effects of ω-3 fatty acids on adipocytes and macrophages in vitro. Insulin-resistant, nondiabetic subjects wer...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 62; no. 5; pp. 1709 - 1717
Main Authors:	Spencer, Michael, Finlin, Brian S., Unal, Resat, Zhu, Beibei, Morris, Andrew J., Shipp, Lindsey R., Lee, Jonah, Walton, R. Grace, Adu, Akosua, Erfani, Rod, Campbell, Marilyn, McGehee, Robert E., Peterson, Charlotte A., Kern, Philip A.
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01.05.2013
Subjects:	Abdominal Fat - blood supply Abdominal Fat - immunology Abdominal Fat - metabolism Abdominal Fat - pathology Adipocytes Adipose tissue Adipose tissues Angiogenesis Inducing Agents - metabolism Angiogenesis Inducing Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Biopsy Blood vessels Body fat Body Mass Index Capillaries - immunology Capillaries - metabolism Capillaries - pathology Cells, Cultured Chemokine CCL2 - blood Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chronic illnesses Coculture Techniques Collagen Cytokines Diabetes Diabetes. Impaired glucose tolerance Dietary Supplements Docosahexaenoic Acids Down-Regulation Drug Combinations Eicosapentaenoic Acid Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - therapeutic use Female Fish oils Fish Oils - therapeutic use Genetic aspects Glucose Human subjects Humans Inflammation Insulin Resistance Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Medical sciences Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - diet therapy Metabolic Syndrome - immunology Metabolic Syndrome - metabolism Middle Aged Muscles - immunology Muscles - metabolism Muscles - pathology Obesity - complications Omega 3 fatty acids Original Research Physiological aspects Plasma RNA, Messenger - metabolism Stains & staining Triglycerides Tumor necrosis factor-TNF United States Endocrinopathy Human Adipose tissue Diabetes mellitus Polyunsaturated fatty acid Lipids Metabolic diseases n-3 fatty acid Fatty acids Target tissue resistance Unsaturated fatty acid Insulin resistance Macrophage
ISSN:	0012-1797, 1939-327X, 1939-327X
Online Access:	Get full text
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