Obesity and COVID-19: what makes obese host so vulnerable?

The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant morta...

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Veröffentlicht in:Immunity & ageing Jg. 18; H. 1; S. 1 - 10
Hauptverfasser: Mohammad, Sameer, Aziz, Rafia, Al Mahri, Saeed, Malik, Shuja Shafi, Haji, Esraa, Khan, Altaf Husain, Khatlani, Tanvir Saleem, Bouchama, Abderrezak
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 04.01.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Aging
Antibodies
Biomedical and Life Sciences
Biomedicine
Body mass index
Body weight
Cardiovascular diseases
Clinical Nutrition
Coronavirus
Coronaviruses
COVID-19
Death
Diabetes mellitus (non-insulin dependent)
Fatalities
Geriatrics/Gerontology
Health aspects
Hypertension
Immunology
Inflammation
Innate and adaptive immunity
Insulin resistance
Medical research
Medicine, Experimental
Microenvironments
Mortality
Obesity
Overweight
Pandemics
Prognosis
Public Health
Review
Risk factors
Type 2 diabetes
United Kingdom > UK
France
China
Innate and adaptive immunity
Obesity
Insulin resistance
Inflammation
Coronavirus
Covid-19
ISSN:1742-4933, 1742-4933
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Zusammenfassung:The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.
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ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-020-00212-x