Obesity and COVID-19: what makes obese host so vulnerable?

The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant morta...

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Vydáno v:	Immunity & ageing Ročník 18; číslo 1; s. 1 - 10
Hlavní autoři:	Mohammad, Sameer, Aziz, Rafia, Al Mahri, Saeed, Malik, Shuja Shafi, Haji, Esraa, Khan, Altaf Husain, Khatlani, Tanvir Saleem, Bouchama, Abderrezak
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 04.01.2021 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Aging Antibodies Biomedical and Life Sciences Biomedicine Body mass index Body weight Cardiovascular diseases Clinical Nutrition Coronavirus Coronaviruses COVID-19 Death Diabetes mellitus (non-insulin dependent) Fatalities Geriatrics/Gerontology Health aspects Hypertension Immunology Inflammation Innate and adaptive immunity Insulin resistance Medical research Medicine, Experimental Microenvironments Mortality Obesity Overweight Pandemics Prognosis Public Health Review Risk factors Type 2 diabetes United Kingdom > UK France China Innate and adaptive immunity Obesity Insulin resistance Inflammation Coronavirus Covid-19
ISSN:	1742-4933, 1742-4933
On-line přístup:	Získat plný text
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Shrnutí:	The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1742-4933 1742-4933
DOI:	10.1186/s12979-020-00212-x