Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier detection of HCC creates more opportunities for curative therapeutic interventions. EVs ar...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 4489 - 12
Main Authors:	Sun, Na, Lee, Yi-Te, Zhang, Ryan Y., Kao, Rueihung, Teng, Pai-Chi, Yang, Yingying, Yang, Peng, Wang, Jasmine J., Smalley, Matthew, Chen, Pin-Jung, Kim, Minhyung, Chou, Shih-Jie, Bao, Lirong, Wang, Jing, Zhang, Xinyue, Qi, Dongping, Palomique, Juvelyn, Nissen, Nicolas, Han, Steven-Huy B., Sadeghi, Saeed, Finn, Richard S., Saab, Sammy, Busuttil, Ronald W., Markovic, Daniela, Elashoff, David, Yu, Hsiao-hua, Li, Huiying, Heaney, Anthony P., Posadas, Edwin, You, Sungyong, Yang, Ju Dong, Pei, Renjun, Agopian, Vatche G., Tseng, Hsian-Rong, Zhu, Yazhen
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.09.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/51 13/62 147/135 147/143 38/39 38/77 49/90 631/1647/350/877 631/67/1504/1610/4029 631/67/2322 692/53/2421 Aged Antibodies Biomarkers, Tumor - genetics Biomarkers, Tumor - isolation & purification Cancer Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Case-Control Studies Chemistry Click Chemistry - instrumentation Click Chemistry - methods Computational Chemistry Computer Simulation Covalence Diagnosis, Differential Digital signatures Dimethylpolysiloxanes - chemistry Disease Progression Early Detection of Cancer - instrumentation Early Detection of Cancer - methods Extracellular vesicles Extracellular Vesicles - genetics Female Hep G2 Cells Hepatocellular carcinoma Humanities and Social Sciences Humans Lab-On-A-Chip Devices Liquid Biopsy - instrumentation Liquid Biopsy - methods Liver cancer Liver Cirrhosis - blood Liver Cirrhosis - pathology Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - pathology Male Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Microfluidics Middle Aged Mixers multidisciplinary Nanostructures - chemistry Nanowires - chemistry Neoplasm Staging Purification Reverse Transcriptase Polymerase Chain Reaction - instrumentation Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics RNA, Messenger - isolation & purification ROC Curve Science Science (multidisciplinary) Substrates Therapeutic applications Vesicles
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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