Central circuit mechanisms of itch

Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at...

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Vydáno v:Nature communications Ročník 11; číslo 1; s. 3052 - 10
Hlavní autoři: Chen, Xiao-Jun, Sun, Yan-Gang
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 16.06.2020
Nature Publishing Group
Nature Portfolio
Témata:
631/378/1689
631/378/2620
64/60
Ablation
Animals
Brain - metabolism
Circuits
Gastrin-Releasing Peptide - genetics
Gastrin-Releasing Peptide - metabolism
Histamine
Humanities and Social Sciences
Humans
multidisciplinary
Nervous system
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Pruritus - etiology
Pruritus - psychology
Receptors, Bombesin - genetics
Receptors, Bombesin - metabolism
Relaying
Review
Review Article
Science
Science (multidisciplinary)
Signal Transduction
Spinal cord
Spinal Cord - metabolism
ISSN:2041-1723, 2041-1723
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Abstract Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels. Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
AbstractList Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.
Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels. Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.
ArticleNumber 3052
Author Sun, Yan-Gang
Chen, Xiao-Jun
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  surname: Chen
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  surname: Sun
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  email: yangang.sun@ion.ac.cn
  organization: Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32546780$$D View this record in MEDLINE/PubMed
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Snippet Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in...
Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal...
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SubjectTerms 631/378/1689
631/378/2620
64/60
Ablation
Animals
Brain - metabolism
Circuits
Gastrin-Releasing Peptide - genetics
Gastrin-Releasing Peptide - metabolism
Histamine
Humanities and Social Sciences
Humans
multidisciplinary
Nervous system
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Pruritus - etiology
Pruritus - psychology
Receptors, Bombesin - genetics
Receptors, Bombesin - metabolism
Relaying
Review
Review Article
Science
Science (multidisciplinary)
Signal Transduction
Spinal cord
Spinal Cord - metabolism
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Title Central circuit mechanisms of itch
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