Central circuit mechanisms of itch

Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at...

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Bibliographic Details
Published in:Nature communications Vol. 11; no. 1; pp. 3052 - 10
Main Authors: Chen, Xiao-Jun, Sun, Yan-Gang
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 16.06.2020
Nature Publishing Group
Nature Portfolio
Subjects:
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631/378/2620
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Ablation
Animals
Brain - metabolism
Circuits
Gastrin-Releasing Peptide - genetics
Gastrin-Releasing Peptide - metabolism
Histamine
Humanities and Social Sciences
Humans
multidisciplinary
Nervous system
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Pruritus - etiology
Pruritus - psychology
Receptors, Bombesin - genetics
Receptors, Bombesin - metabolism
Relaying
Review
Review Article
Science
Science (multidisciplinary)
Signal Transduction
Spinal cord
Spinal Cord - metabolism
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels. Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-020-16859-5