Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation

Polymorphisms of the ABCG5 and ABCG8 genes interfere with cholesterol absorption and synthesis. We determined whether common polymorphisms of these genes regulate the responses of serum cholesterol and vascular function during long-term inhibition of cholesterol absorption. Mildly to moderately hype...

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Bibliographic Details
Published in:	British journal of nutrition Vol. 101; no. 11; pp. 1688 - 1695
Main Authors:	Gylling, Helena, Hallikainen, Maarit, Raitakari, Olli T, Laakso, Markku, Vartiainen, Erkki, Salo, Pia, Korpelainen, Vesa, Sundvall, Jouko, Miettinen, Tatu A
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 14.06.2009
Subjects:	Absorption Adult Aged ATP Binding Cassette Transporter, Sub-Family G, Member 5 ATP Binding Cassette Transporter, Sub-Family G, Member 8 ATP-Binding Cassette Transporters ATP-Binding Cassette Transporters - genetics Biological and medical sciences blood Blood pressure Brachial Artery Brachial Artery - drug effects Brachial Artery - physiopathology Cardiovascular disease cardiovascular system Carotid Arteries Carotid Arteries - drug effects Carotid Arteries - physiopathology Cholesterol Cholesterol - blood Cholesterol absorption diet therapy Double-Blind Method drug effects Esters Fatty acids Feeding. Feeding behavior Female Food, Fortified Fundamental and applied biological sciences. Psychology gene expression regulation Gene Expression Regulation - drug effects genes genetics Humans hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - diet therapy Hypercholesterolemia - genetics Hypercholesterolemia - physiopathology ingestion Intima media thickness Lipids Lipoproteins Lipoproteins - genetics long term effects Male Margarine Middle Aged nutrition-genotype interaction pathology pharmacology physiopathology Phytosterol esters Phytosterols Phytosterols - pharmacology plant-based foods Polymorphism Polymorphism, Genetic Proteins Public health Sitosterols Sitosterols - pharmacology stanols Sterols Tunica Intima Tunica Intima - pathology Tunica Media Tunica Media - pathology Vascular function Vasodilation Vasodilation - drug effects Vasodilation - genetics Vertebrates: anatomy and physiology, studies on body, several organs or systems United States > US Finland Long term Intima media thickness Ester Vertebrata Plant Regulation(control) Mammalia Food intake function Phytosterol esters Genetics Cholesterol absorption Sterol
ISSN:	0007-1145, 1475-2662, 1475-2662
Online Access:	Get full text
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