Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials

The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects o...

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Veröffentlicht in:Clinical nutrition (Edinburgh, Scotland) Jg. 27; H. 1; S. 57 - 64
Hauptverfasser: Ma, De-Fu, Qin, Li-Qiang, Wang, Pei-Yu, Katoh, Ryohei
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Kidlington Elsevier Ltd 01.02.2008
Elsevier
Schlagworte:
Biological and medical sciences
Bone Density - drug effects
Bone mineral content
Bone mineral density
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Glycine max - chemistry
Humans
Investigative techniques, diagnostic techniques (general aspects)
Isoflavone
Isoflavones - pharmacology
Medical sciences
Menopause
Middle Aged
Osteoarticular system. Muscles
Osteoporosis
Osteoporosis, Postmenopausal - drug therapy
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Randomized Controlled Trials as Topic
Time Factors
Treatment Outcome
Vertebrates: anatomy and physiology, studies on body, several organs or systems
SBMD
Isoflavone
Bone mineral content
Osteoporosis
SBMC
RCTs
Bone mineral density
randomized controlled trials
spine bone mineral content
spine bone mineral density
Consumption
Human
Spine
Metabolic diseases
Increase
Soybean
Metaanalysis
Osteoarticular system
Randomization
Clinical trial
Female
Woman
ISSN:0261-5614, 1532-1983, 1532-1983
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Zusammenfassung:The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software. Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm 2 (95% confidence interval: 4.5–36.6 mg/cm 2) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: −0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm 2 (95% confidence interval: 8.4–48.6 mg/cm 2) and 27 mg/cm 2 (95% confidence interval: 8.3–45.8 mg/cm 2), respectively. Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women.
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ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2007.10.012