Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials

The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects o...

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Vydáno v:	Clinical nutrition (Edinburgh, Scotland) Ročník 27; číslo 1; s. 57 - 64
Hlavní autoři:	Ma, De-Fu, Qin, Li-Qiang, Wang, Pei-Yu, Katoh, Ryohei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 01.02.2008 Elsevier
Témata:	Biological and medical sciences Bone Density - drug effects Bone mineral content Bone mineral density Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glycine max - chemistry Humans Investigative techniques, diagnostic techniques (general aspects) Isoflavone Isoflavones - pharmacology Medical sciences Menopause Middle Aged Osteoarticular system. Muscles Osteoporosis Osteoporosis, Postmenopausal - drug therapy Radiodiagnosis. Nmr imagery. Nmr spectrometry Randomized Controlled Trials as Topic Time Factors Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems SBMD Isoflavone Bone mineral content Osteoporosis SBMC RCTs Bone mineral density randomized controlled trials spine bone mineral content spine bone mineral density Consumption Human Spine Metabolic diseases Increase Soybean Metaanalysis Osteoarticular system Randomization Clinical trial Female Woman
ISSN:	0261-5614, 1532-1983, 1532-1983
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Shrnutí:	The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software. Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm 2 (95% confidence interval: 4.5–36.6 mg/cm 2) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: −0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm 2 (95% confidence interval: 8.4–48.6 mg/cm 2) and 27 mg/cm 2 (95% confidence interval: 8.3–45.8 mg/cm 2), respectively. Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0261-5614 1532-1983 1532-1983
DOI:	10.1016/j.clnu.2007.10.012