Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses, have an established role in this process. While the microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized as...

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Veröffentlicht in:	The EMBO journal Jg. 39; H. 16; S. e105380 - n/a
Hauptverfasser:	Scott‐Hewitt, Nicole, Perrucci, Fabio, Morini, Raffaella, Erreni, Marco, Mahoney, Matthew, Witkowska, Agata, Carey, Alanna, Faggiani, Elisa, Schuetz, Lisa Theresia, Mason, Sydney, Tamborini, Matteo, Bizzotto, Matteo, Passoni, Lorena, Filipello, Fabia, Jahn, Reinhard, Stevens, Beth, Matteoli, Michela
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.08.2020 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	Animals Annexin V C1q Caspase-3 Circuits Coculture Techniques Complement C1q - genetics Complement C1q - metabolism Complement C3 - genetics Complement C3 - metabolism Complement component C1q Complement component C3 EMBO19 EMBO27 Exposure Hippocampus Hippocampus - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout Microglia Microglia - metabolism Neural networks Neurons - metabolism Phosphatidylserine Phosphatidylserines - genetics Phosphatidylserines - metabolism Pruning Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Supernumerary Synapse elimination synapse pruning Synapses Synapses - genetics Synapses - metabolism Synaptogenesis TREM2 Visual pathways Visual system phosphatidylserine synapse pruning C1q TREM2 microglia
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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