Engineered cells as biosensing systems in biomedical analysis

Over the past two decades there have been great advances in biotechnology, including use of nucleic acids, proteins, and whole cells to develop a variety of molecular analytical tools for diagnostic, screening, and pharmaceutical applications. Through manipulation of bacterial plasmids and genomes,...

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Published in:	Analytical and bioanalytical chemistry Vol. 402; no. 10; pp. 3147 - 3159
Main Authors:	Raut, Nilesh, O’Connor, Gregory, Pasini, Patrizia, Daunert, Sylvia
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.04.2012 Springer
Subjects:	Analysis Analytical Chemistry Animals Antibacterial agents Assessments Bacteria Bacteria - genetics Bacterial Physiological Phenomena Biochemistry Biomedical Research Biosensing Techniques - instrumentation Biosensing Techniques - methods Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cost analysis Detection Food Science Genes, Reporter Genetic Engineering Genomes Humans Laboratory Medicine Mathematical analysis Miniaturization Monitoring/Environmental Analysis Plasmids - genetics Plasmids - metabolism Proteins Quorum Sensing Review Screening Technology application Hydroxylated polychlorinated biphenyls Whole-cell sensing system Quorum sensing molecules Cytarabine Antibiotics Biomedical analysis Mercury
ISSN:	1618-2642, 1618-2650, 1618-2650
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Abstract	Over the past two decades there have been great advances in biotechnology, including use of nucleic acids, proteins, and whole cells to develop a variety of molecular analytical tools for diagnostic, screening, and pharmaceutical applications. Through manipulation of bacterial plasmids and genomes, bacterial whole-cell sensing systems have been engineered that can serve as novel methods for analyte detection and characterization, and as more efficient and cost-effective alternatives to traditional analytical techniques. Bacterial cell-based sensing systems are typically sensitive, specific and selective, rapid, easy to use, low-cost, and amenable to multiplexing, high-throughput, and miniaturization for incorporation into portable devices. This critical review is intended to provide an overview of available bacterial whole-cell sensing systems for assessment of a variety of clinically relevant analytes. Specifically, we examine whole-cell sensing systems for detection of bacterial quorum sensing molecules, organic and inorganic toxic compounds, and drugs, and for screening of antibacterial compounds for identification of their mechanisms of action. Methods used in the design and development of whole-cell sensing systems are also reviewed.
AbstractList	Over the past two decades there have been great advances in biotechnology, including use of nucleic acids, proteins, and whole cells to develop a variety of molecular analytical tools for diagnostic, screening, and pharmaceutical applications. Through manipulation of bacterial plasmids and genomes, bacterial whole-cell sensing systems have been engineered that can serve as novel methods for analyte detection and characterization, and as more efficient and cost-effective alternatives to traditional analytical techniques. Bacterial cell-based sensing systems are typically sensitive, specific and selective, rapid, easy to use, low-cost, and amenable to multiplexing, high-throughput, and miniaturization for incorporation into portable devices. This critical review is intended to provide an overview of available bacterial whole-cell sensing systems for assessment of a variety of clinically relevant analytes. Specifically, we examine whole-cell sensing systems for detection of bacterial quorum sensing molecules, organic and inorganic toxic compounds, and drugs, and for screening of antibacterial compounds for identification of their mechanisms of action. Methods used in the design and development of whole-cell sensing systems are also reviewed. Over the past two decades there have been great advances in biotechnology, including use of nucleic acids, proteins, and whole cells to develop a variety of molecular analytical tools for diagnostic, screening, and pharmaceutical applications. Through manipulation of bacterial plasmids and genomes, bacterial whole-cell sensing systems have been engineered that can serve as novel methods for analyte detection and characterization, and as more efficient and cost-effective alternatives to traditional analytical techniques. Bacterial cell-based sensing systems are typically sensitive, specific and selective, rapid, easy to use, low-cost, and amenable to multiplexing, high-throughput, and miniaturization for incorporation into portable devices. This critical review is intended to provide an overview of available bacterial whole-cell sensing systems for assessment of a variety of clinically relevant analytes. Specifically, we examine whole-cell sensing systems for detection of bacterial quorum sensing molecules, organic and inorganic toxic compounds, and drugs, and for screening of antibacterial compounds for identification of their mechanisms of action. Methods used in the design and development of whole-cell sensing systems are also reviewed.Over the past two decades there have been great advances in biotechnology, including use of nucleic acids, proteins, and whole cells to develop a variety of molecular analytical tools for diagnostic, screening, and pharmaceutical applications. Through manipulation of bacterial plasmids and genomes, bacterial whole-cell sensing systems have been engineered that can serve as novel methods for analyte detection and characterization, and as more efficient and cost-effective alternatives to traditional analytical techniques. Bacterial cell-based sensing systems are typically sensitive, specific and selective, rapid, easy to use, low-cost, and amenable to multiplexing, high-throughput, and miniaturization for incorporation into portable devices. This critical review is intended to provide an overview of available bacterial whole-cell sensing systems for assessment of a variety of clinically relevant analytes. Specifically, we examine whole-cell sensing systems for detection of bacterial quorum sensing molecules, organic and inorganic toxic compounds, and drugs, and for screening of antibacterial compounds for identification of their mechanisms of action. Methods used in the design and development of whole-cell sensing systems are also reviewed.
Audience	Academic
Author	Pasini, Patrizia Raut, Nilesh O’Connor, Gregory Daunert, Sylvia
Author_xml	– sequence: 1 givenname: Nilesh surname: Raut fullname: Raut, Nilesh organization: Department of Chemistry, University of Kentucky – sequence: 2 givenname: Gregory surname: O’Connor fullname: O’Connor, Gregory organization: Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami – sequence: 3 givenname: Patrizia surname: Pasini fullname: Pasini, Patrizia organization: Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami – sequence: 4 givenname: Sylvia surname: Daunert fullname: Daunert, Sylvia email: sdaunert@med.miami.edu organization: Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami
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Keywords	Hydroxylated polychlorinated biphenyls Whole-cell sensing system Quorum sensing molecules Cytarabine Antibiotics Biomedical analysis Mercury
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SubjectTerms	Analysis Analytical Chemistry Animals Antibacterial agents Assessments Bacteria Bacteria - genetics Bacterial Physiological Phenomena Biochemistry Biomedical Research Biosensing Techniques - instrumentation Biosensing Techniques - methods Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cost analysis Detection Food Science Genes, Reporter Genetic Engineering Genomes Humans Laboratory Medicine Mathematical analysis Miniaturization Monitoring/Environmental Analysis Plasmids - genetics Plasmids - metabolism Proteins Quorum Sensing Review Screening Technology application
Title	Engineered cells as biosensing systems in biomedical analysis
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