FAM13A affects body fat distribution and adipocyte function
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcuta...
Saved in:
| Published in: | Nature communications Vol. 11; no. 1; pp. 1465 - 13 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
19.03.2020
Nature Publishing Group Nature Portfolio |
| Subjects: | |
| ISSN: | 2041-1723, 2041-1723 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Genetic variation in the
FAM13A
(Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans,
FAM13A
alleles are associated with increased
FAM13A
expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of
FAM13A
in preadipocytes accelerates adipocyte differentiation. In mice,
Fam13a
knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the
FAM13A
locus alter adipose
FAM13A
expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.
Genetic variants in the
FAM13A
locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. |
|---|---|
| AbstractList | Genetic variation in the
FAM13A
(Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans,
FAM13A
alleles are associated with increased
FAM13A
expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of
FAM13A
in preadipocytes accelerates adipocyte differentiation. In mice,
Fam13a
knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the
FAM13A
locus alter adipose
FAM13A
expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.
Genetic variants in the
FAM13A
locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. |
| ArticleNumber | 1465 |
| Author | Rao, Abhiram Quertermous, Thomas Chennamsetty, Indumathi Zhou, Xiang Reilly, Dermot Wabitsch, Martin Seldin, Marcus Li, Jiehan Cook, Naomi Knowles, Joshua W. Attie, Allan Tada, Yuko McLaughlin, Tracey Ingelsson, Erik Gloudemans, Michael J. Keller, Mark Shin, Myung Kyun Fathzadeh, Mohsen Reaven, Gerald Carcamo-Orive, Ivan Molony, Cliona M. Montgomery, Stephen B. Lusis, Aldons J. Sangwung, Panjamaporn Yang, Jing |
| Author_xml | – sequence: 1 givenname: Mohsen orcidid: 0000-0002-7962-9148 surname: Fathzadeh fullname: Fathzadeh, Mohsen organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 2 givenname: Jiehan surname: Li fullname: Li, Jiehan organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 3 givenname: Abhiram surname: Rao fullname: Rao, Abhiram organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Bioengineering Department, School of Engineering and Medicine – sequence: 4 givenname: Naomi orcidid: 0000-0002-1830-2432 surname: Cook fullname: Cook, Naomi organization: Department of Medical Sciences, Molecular Epidemiology, Uppsala University – sequence: 5 givenname: Indumathi surname: Chennamsetty fullname: Chennamsetty, Indumathi organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University – sequence: 6 givenname: Marcus orcidid: 0000-0001-8026-4759 surname: Seldin fullname: Seldin, Marcus organization: Department of Human Genetics, David Geffen School of Medicine, UCLA – sequence: 7 givenname: Xiang surname: Zhou fullname: Zhou, Xiang organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University – sequence: 8 givenname: Panjamaporn orcidid: 0000-0002-8145-7947 surname: Sangwung fullname: Sangwung, Panjamaporn organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 9 givenname: Michael J. orcidid: 0000-0002-9924-9943 surname: Gloudemans fullname: Gloudemans, Michael J. organization: Department of Genetics, Stanford University – sequence: 10 givenname: Mark surname: Keller fullname: Keller, Mark organization: Department of Biochemistry, University of Wisconsin – sequence: 11 givenname: Allan orcidid: 0000-0002-0568-2261 surname: Attie fullname: Attie, Allan organization: Department of Biochemistry, University of Wisconsin – sequence: 12 givenname: Jing orcidid: 0000-0002-4983-1660 surname: Yang fullname: Yang, Jing organization: Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana–Champaign – sequence: 13 givenname: Martin surname: Wabitsch fullname: Wabitsch, Martin organization: Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Ulm – sequence: 14 givenname: Ivan orcidid: 0000-0001-8823-4925 surname: Carcamo-Orive fullname: Carcamo-Orive, Ivan organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 15 givenname: Yuko orcidid: 0000-0003-1410-9894 surname: Tada fullname: Tada, Yuko organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University – sequence: 16 givenname: Aldons J. orcidid: 0000-0001-9013-0228 surname: Lusis fullname: Lusis, Aldons J. organization: Department of Human Genetics, David Geffen School of Medicine, UCLA – sequence: 17 givenname: Myung Kyun surname: Shin fullname: Shin, Myung Kyun organization: Genetics and Pharmacogenomics, Merck & Co., Inc – sequence: 18 givenname: Cliona M. surname: Molony fullname: Molony, Cliona M. organization: Genetics and Pharmacogenomics, Merck & Co., Inc – sequence: 19 givenname: Tracey surname: McLaughlin fullname: McLaughlin, Tracey organization: Stanford Diabetes Research Center, Stanford University, Department of Medicine, Division of Endocrinology, Stanford University School of Medicine – sequence: 20 givenname: Gerald surname: Reaven fullname: Reaven, Gerald organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 21 givenname: Stephen B. orcidid: 0000-0002-5200-3903 surname: Montgomery fullname: Montgomery, Stephen B. organization: Stanford Diabetes Research Center, Stanford University, Department of Genetics, Stanford University, Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Department of Pathology, Stanford University – sequence: 22 givenname: Dermot orcidid: 0000-0002-9456-1364 surname: Reilly fullname: Reilly, Dermot organization: Genetics and Pharmacogenomics, Merck & Co., Inc – sequence: 23 givenname: Thomas orcidid: 0000-0002-7645-9067 surname: Quertermous fullname: Quertermous, Thomas organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 24 givenname: Erik orcidid: 0000-0003-2256-6972 surname: Ingelsson fullname: Ingelsson, Erik email: eriking@stanford.edu organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University – sequence: 25 givenname: Joshua W. orcidid: 0000-0003-1922-7240 surname: Knowles fullname: Knowles, Joshua W. email: knowlej@stanford.edu organization: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford Diabetes Research Center, Stanford University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32193374$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409711$$DView record from Swedish Publication Index (Uppsala universitet) |
| BookMark | eNp9kktv1DAUhSNUREvpH2CBIrFh0YCvH3EiJKRRS6FSERtga9049uBRJh5sBzT99XgelE4X9SbOzXdOjn3v8-Jo9KMpipdA3gJhzbvIgdeyIpRUIGgL1e2T4oQSDhVIyo7u7Y-LsxgXJC_WQsP5s-KYUWgZk_ykeH81-wJsVqK1RqdYdr5flxZT2buYguum5PxY4tiX2LuV1-tkSjuNelN-UTy1OERztn-eFt-vPn67-FzdfP10fTG7qbSQMlVIWW1ojZoLhI51TS0EWtIL7KwkLeNG6zq_aSCWAu_B1hS5zHm0gJYKdlpc73x7jwu1Cm6JYa08OrUt-DBXGJLTg1Gdhr6jJh-bI7eSoZQtl0SQVgjOKWav851X_GNWU3fgdul-zLZu06Q4aSVAxj_s8MwuTa_NmAIOB6rDL6P7qeb-t5KkAQqb7G_2BsH_mkxMaumiNsOAo_FTVJQ1UFPeSp7R1w_QhZ_CmG82U7IVuXtCZurV_UR3Uf61NAN0B-jgYwzG3iFA1GZ01G50VB4dtR0ddZtFzQORdgk3Tc6ncsPjUra_0fyfcW7C_9iPqP4CrQTWwA |
| CitedBy_id | crossref_primary_10_3389_fphar_2021_707507 crossref_primary_10_3390_ijms21249740 crossref_primary_10_1165_rcmb_2024_0166ED crossref_primary_10_1039_D4FO04489D crossref_primary_10_1186_s13578_025_01399_6 crossref_primary_10_1186_s13073_022_01036_8 crossref_primary_10_1007_s40618_020_01446_8 crossref_primary_10_1186_s12885_025_13903_9 crossref_primary_10_1016_j_jacc_2021_03_346 crossref_primary_10_1016_j_ajhg_2021_08_014 crossref_primary_10_3390_ijms23031271 crossref_primary_10_1016_j_molmet_2022_101531 crossref_primary_10_3390_ani13030446 crossref_primary_10_1161_CIRCRESAHA_123_323973 crossref_primary_10_1038_s41591_025_03931_0 crossref_primary_10_1007_s11250_025_04571_9 crossref_primary_10_3390_life15081312 crossref_primary_10_3390_nu17010198 crossref_primary_10_1038_s41591_024_02865_3 crossref_primary_10_7554_eLife_79834 crossref_primary_10_1016_j_pnpbp_2025_111317 crossref_primary_10_3892_mmr_2021_12543 crossref_primary_10_1002_ece3_9639 crossref_primary_10_1038_s42255_021_00346_2 crossref_primary_10_1016_j_molmet_2023_101824 crossref_primary_10_1038_s42255_023_00807_w crossref_primary_10_1016_j_cca_2020_10_028 crossref_primary_10_3390_biom13071057 crossref_primary_10_1016_j_abb_2021_108885 crossref_primary_10_3389_fendo_2021_737624 crossref_primary_10_3390_cells14110760 crossref_primary_10_1016_j_bbrc_2023_02_068 crossref_primary_10_1016_j_jevs_2025_105658 crossref_primary_10_1038_s41588_023_01625_2 crossref_primary_10_3390_genes14040914 |
| Cites_doi | 10.1111/joim.12827 10.1194/jlr.D023788 10.1038/ng.2797 10.1007/s00125-018-4572-8 10.1159/000145784 10.1016/j.cels.2016.02.002 10.2337/db14-0318 10.1016/j.ajhg.2016.10.003 10.1016/j.ajhg.2017.01.027 10.1007/s00125-012-2639-5 10.1016/j.cell.2013.12.012 10.1091/mbc.E14-08-1276 10.1038/ng.3714 10.1038/srep14841 10.1073/pnas.1720475115 10.1074/jbc.M113.534172 10.1016/j.stem.2017.01.010 10.1038/nprot.2016.117 10.1371/journal.pgen.1000754 10.1038/ng.535 10.1074/mcp.M113.035600 10.1038/nrm2391 10.1136/jmedgenet-2014-102525 10.1002/mgg3.543 10.3389/fnut.2016.00010 10.1038/s41366-018-0222-y 10.1186/1471-2105-9-559 10.1093/bioinformatics/btp616 10.1016/S0021-9258(18)41516-5 10.1016/S0092-8674(03)00271-X 10.1093/bioinformatics/bts635 10.1038/ng.2385 10.1038/nm.2899 10.1097/01.mjt.0000178781.89789.25 10.1371/journal.pgen.1007079 10.1074/jbc.M103241200 10.1194/jlr.O072629 10.1016/j.cell.2014.09.029 10.1038/nature14132 10.7554/eLife.12677 10.1371/journal.pmed.1001779 10.1079/BJN19830006 10.1126/scitranslmed.3008490 10.1016/j.tem.2008.09.002 10.1172/JCI74692 10.1038/sj.ijo.0801520 10.1038/ng880 10.1038/s41588-018-0088-x 10.1172/JCI32239 10.1016/j.molmet.2016.05.004 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM ACNBI ADTPV AOWAS D8T DF2 ZZAVC DOA |
| DOI | 10.1038/s41467-020-15291-z |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection PML(ProQuest Medical Library) Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SWEPUB Uppsala universitet full text SwePub SwePub Articles SWEPUB Freely available online SWEPUB Uppsala universitet SwePub Articles full text DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 13 |
| ExternalDocumentID | oai_doaj_org_article_bc1db2e1724a4f73a77947050955442a oai_DiVA_org_uu_409711 PMC7081215 32193374 10_1038_s41467_020_15291_z |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: This study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK107437 and 1R01DK106236), the Stanford Diabetes Research Center (NIDDK award P30DK116074), and an unrestricted grant from Merck. – fundername: U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) grantid: R01DK107437; R01DK106236; P30DK116074 funderid: https://doi.org/10.13039/100000062 – fundername: U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) – fundername: Merck (Merck & Co., Inc.) funderid: https://doi.org/10.13039/100004334 – fundername: NIDDK NIH HHS grantid: R01 DK107437 – fundername: NLM NIH HHS grantid: T15 LM007033 – fundername: NIDDK NIH HHS grantid: P30 DK116074 – fundername: NIDDK NIH HHS grantid: R01 DK106236 – fundername: NIDDK NIH HHS grantid: R01 DK101573 – fundername: NIGMS NIH HHS grantid: R35 GM131810 – fundername: NIDDK NIH HHS grantid: R01 DK120565 – fundername: NIDDK NIH HHS grantid: R01 DK116750 – fundername: ; – fundername: ; grantid: R01DK107437; R01DK106236; P30DK116074 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM 4.4 ACNBI ADTPV AOWAS BAPOH CAG COF D8T DF2 EJD LGEZI LOTEE NADUK NXXTH ZZAVC |
| ID | FETCH-LOGICAL-c577t-a236e26ac45a1b3b8655af0d5abf70934ecc6d5ac10f214d1f62a47fecc519253 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 47 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000522138100013&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2041-1723 |
| IngestDate | Mon Nov 10 04:32:44 EST 2025 Tue Nov 04 16:57:45 EST 2025 Tue Nov 04 02:00:51 EST 2025 Thu Oct 02 05:22:29 EDT 2025 Sat Nov 29 14:25:54 EST 2025 Mon Jul 21 05:50:50 EDT 2025 Sat Nov 29 06:20:19 EST 2025 Tue Nov 18 21:20:03 EST 2025 Fri Feb 21 02:39:59 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c577t-a236e26ac45a1b3b8655af0d5abf70934ecc6d5ac10f214d1f62a47fecc519253 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-8145-7947 0000-0002-4983-1660 0000-0002-1830-2432 0000-0003-2256-6972 0000-0003-1410-9894 0000-0002-9924-9943 0000-0002-5200-3903 0000-0001-8026-4759 0000-0002-0568-2261 0000-0001-8823-4925 0000-0002-7645-9067 0000-0001-9013-0228 0000-0002-9456-1364 0000-0003-1922-7240 0000-0002-7962-9148 |
| OpenAccessLink | https://www.proquest.com/docview/2379539157?pq-origsite=%requestingapplication% |
| PMID | 32193374 |
| PQID | 2379539157 |
| PQPubID | 546298 |
| PageCount | 13 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_bc1db2e1724a4f73a77947050955442a swepub_primary_oai_DiVA_org_uu_409711 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7081215 proquest_miscellaneous_2381624974 proquest_journals_2379539157 pubmed_primary_32193374 crossref_primary_10_1038_s41467_020_15291_z crossref_citationtrail_10_1038_s41467_020_15291_z springer_journals_10_1038_s41467_020_15291_z |
| PublicationCentury | 2000 |
| PublicationDate | 2020-03-19 |
| PublicationDateYYYYMMDD | 2020-03-19 |
| PublicationDate_xml | – month: 03 year: 2020 text: 2020-03-19 day: 19 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Rao (CR12) 2018; 11 Bourgeois, Alexiu, Lemonnier (CR46) 1983; 49 Warren (CR24) 2017; 20 Zhang (CR8) 2019; 7 Scott (CR3) 2012; 44 Tang (CR36) 2019; 43 Laakso (CR14) 2017; 58 Cao (CR23) 2007; 117 Knowles (CR47) 2015; 125 Cautivo (CR21) 2016; 5 Guilherme, Virbasius, Puri, Czech (CR28) 2008; 9 Willer (CR6) 2013; 45 Kaess (CR27) 2012; 55 Fagerberg (CR9) 2014; 13 Agarwal (CR20) 2002; 31 Lundback (CR38) 2018; 61 Mardinoglu (CR26) 2015; 5 Clee, Nadler, Attie (CR50) 2005; 12 Chusyd, Wang, Huffman, Nagy (CR39) 2016; 3 Robinson, McCarthy, Smyth (CR49) 2010; 26 Loos, Kilpelainen (CR2) 2018; 284 Galarraga (CR45) 2012; 53 Christodoulides, Lagathu, Sethi, Vidal-Puig (CR35) 2009; 20 Yamauchi (CR31) 2001; 276 Shungin (CR1) 2015; 518 Hägg (CR16) 2009; 5 Jin (CR43) 2015; 26 Li, Daly, Campioli, Wabitsch, Papadopoulos (CR51) 2014; 289 Dobin (CR48) 2013; 29 Corvol, Hodges, Drumm, Guillot (CR33) 2014; 51 Rao (CR40) 2018; 11 Gilbert (CR54) 2014; 159 Sudlow (CR11) 2015; 12 Langfelder, Horvath (CR42) 2008; 9 Shepherd (CR29) 1993; 268 Kusminski (CR30) 2012; 18 Fischer-Posovszky, Newell, Wabitsch, Tornqvist (CR52) 2008; 1 Horlbeck (CR53) 2016; 5 Cho (CR7) 2010; 42 Civelek (CR19) 2017; 100 Rosen, Spiegelman (CR32) 2014; 156 Herwig, Hardt, Lienhard, Kamburov (CR15) 2016; 11 Ussar (CR22) 2014; 6 Hormozdiari (CR10) 2016; 99 Davis (CR13) 2017; 13 Wardhana (CR37) 2018; 115 Lotta (CR4) 2017; 49 Yaghootkar (CR5) 2014; 63 Fischer (CR25) 2017; 8 Wabitsch (CR17) 2001; 25 Fischer, Jacobson, Rose, Zeller (CR44) 2008; 2008 Sordella, Jiang, Chen, Curto, Settleman (CR34) 2003; 113 Small (CR18) 2018; 50 Talukdar (CR41) 2016; 2 AS Rao (15291_CR40) 2018; 11 J Li (15291_CR51) 2014; 289 Y Zhang (15291_CR8) 2019; 7 S Ussar (15291_CR22) 2014; 6 Y Cao (15291_CR23) 2007; 117 KS Small (15291_CR18) 2018; 50 DA Wardhana (15291_CR37) 2018; 115 L Fagerberg (15291_CR9) 2014; 13 H Yaghootkar (15291_CR5) 2014; 63 BM Kaess (15291_CR27) 2012; 55 M Laakso (15291_CR14) 2017; 58 M Wabitsch (15291_CR17) 2001; 25 M Civelek (15291_CR19) 2017; 100 R Sordella (15291_CR34) 2003; 113 A Guilherme (15291_CR28) 2008; 9 A Mardinoglu (15291_CR26) 2015; 5 F Bourgeois (15291_CR46) 1983; 49 LA Lotta (15291_CR4) 2017; 49 R Herwig (15291_CR15) 2016; 11 M Galarraga (15291_CR45) 2012; 53 MH Cho (15291_CR7) 2010; 42 S Hägg (15291_CR16) 2009; 5 J Tang (15291_CR36) 2019; 43 V Lundback (15291_CR38) 2018; 61 HA Talukdar (15291_CR41) 2016; 2 CR Warren (15291_CR24) 2017; 20 T Yamauchi (15291_CR31) 2001; 276 Z Jin (15291_CR43) 2015; 26 AK Agarwal (15291_CR20) 2002; 31 RJF Loos (15291_CR2) 2018; 284 C Fischer (15291_CR25) 2017; 8 PR Shepherd (15291_CR29) 1993; 268 SM Clee (15291_CR50) 2005; 12 D Shungin (15291_CR1) 2015; 518 P Langfelder (15291_CR42) 2008; 9 AS Rao (15291_CR12) 2018; 11 MD Robinson (15291_CR49) 2010; 26 MA Horlbeck (15291_CR53) 2016; 5 CJ Willer (15291_CR6) 2013; 45 A Dobin (15291_CR48) 2013; 29 KM Cautivo (15291_CR21) 2016; 5 JP Davis (15291_CR13) 2017; 13 JW Knowles (15291_CR47) 2015; 125 F Hormozdiari (15291_CR10) 2016; 99 P Fischer-Posovszky (15291_CR52) 2008; 1 LA Gilbert (15291_CR54) 2014; 159 CM Kusminski (15291_CR30) 2012; 18 AH Fischer (15291_CR44) 2008; 2008 ED Rosen (15291_CR32) 2014; 156 C Sudlow (15291_CR11) 2015; 12 H Corvol (15291_CR33) 2014; 51 C Christodoulides (15291_CR35) 2009; 20 DE Chusyd (15291_CR39) 2016; 3 RA Scott (15291_CR3) 2012; 44 |
| References_xml | – volume: 13 start-page: e1007079 year: 2017 ident: CR13 article-title: Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study publication-title: PLoS Genet. – volume: 2 start-page: 196 year: 2016 end-page: 208 ident: CR41 article-title: Cross-tissue regulatory gene networks in coronary artery disease publication-title: Cell Syst. – volume: 51 start-page: 646 year: 2014 end-page: 649 ident: CR33 article-title: Moving beyond genetics: is FAM13A a major biological contributor in lung physiology and chronic lung diseases? publication-title: J. Med. Genet. – volume: 55 start-page: 2622 year: 2012 end-page: 2630 ident: CR27 article-title: The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk publication-title: Diabetologia – volume: 20 start-page: 547 year: 2017 end-page: 557 e547 ident: CR24 article-title: Induced pluripotent stem cell differentiation enables functional validation of GWAS variants in metabolic disease publication-title: Cell Stem Cell – volume: 6 start-page: 247ra103 year: 2014 ident: CR22 article-title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes publication-title: Sci. Transl. Med. – volume: 11 start-page: 1889 year: 2016 end-page: 1907 ident: CR15 article-title: Analyzing and interpreting genome data at the network level with ConsensusPathDB publication-title: Nat. Protoc. – volume: 20 start-page: 16 year: 2009 end-page: 24 ident: CR35 article-title: Adipogenesis and WNT signalling publication-title: Trends Endocrinol. Metab. – volume: 63 start-page: 4369 year: 2014 end-page: 4377 ident: CR5 article-title: Genetic evidence for a normal-weight “metabolically obese” phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes publication-title: Diabetes – volume: 8 year: 2017 ident: CR25 article-title: A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning publication-title: Nat. Commun. – volume: 268 start-page: 22243 year: 1993 end-page: 22246 ident: CR29 article-title: Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue publication-title: J. Biol. Chem. – volume: 12 start-page: e1001779 year: 2015 ident: CR11 article-title: UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age publication-title: PLoS Med. – volume: 58 start-page: 481 year: 2017 end-page: 493 ident: CR14 article-title: The metabolic syndrome in men study: a resource for studies of metabolic and cardiovascular diseases publication-title: J. Lipid Res. – volume: 5 start-page: 491 year: 2016 end-page: 505 ident: CR21 article-title: AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue publication-title: Mol. Metab. – volume: 26 start-page: 1160 year: 2015 end-page: 1173 ident: CR43 article-title: Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt publication-title: Mol. Biol. Cell – volume: 156 start-page: 20 year: 2014 end-page: 44 ident: CR32 article-title: What we talk about when we talk about fat publication-title: Cell – volume: 9 start-page: 367 year: 2008 end-page: 377 ident: CR28 article-title: Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes publication-title: Nat. Rev. Mol. Cell Biol. – volume: 12 start-page: 491 year: 2005 end-page: 498 ident: CR50 article-title: Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetes publication-title: Am. J. Ther. – volume: 159 start-page: 647 year: 2014 end-page: 661 ident: CR54 article-title: Genome-Scale CRISPR-mediated control of gene repression and activation publication-title: Cell – volume: 2008 start-page: pdb prot4986 year: 2008 ident: CR44 article-title: Hematoxylin and eosin staining of tissue and cell sections publication-title: CSH Protoc. – volume: 125 start-page: 1739 year: 2015 end-page: 1751 ident: CR47 article-title: Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene publication-title: J. Clin. Invest. – volume: 276 start-page: 41245 year: 2001 end-page: 41254 ident: CR31 article-title: The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance publication-title: J. Biol. Chem. – volume: 53 start-page: 2791 year: 2012 end-page: 2796 ident: CR45 article-title: Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections publication-title: J. Lipid Res. – volume: 61 start-page: 1112 year: 2018 end-page: 1123 ident: CR38 article-title: FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study publication-title: Diabetologia – volume: 99 start-page: 1245 year: 2016 end-page: 1260 ident: CR10 article-title: Colocalization of GWAS and eQTL signals detects target genes publication-title: Am. J. Hum. Genet. – volume: 5 year: 2015 ident: CR26 article-title: Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue publication-title: Sci. Rep. – volume: 18 start-page: 1539 year: 2012 end-page: 1549 ident: CR30 article-title: MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity publication-title: Nat. Med. – volume: 45 start-page: 1274 year: 2013 end-page: 1283 ident: CR6 article-title: Discovery and refinement of loci associated with lipid levels publication-title: Nat. Genet. – volume: 31 start-page: 21 year: 2002 end-page: 23 ident: CR20 article-title: AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34 publication-title: Nat. Genet. – volume: 44 start-page: 991 year: 2012 end-page: 1005 ident: CR3 article-title: Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways publication-title: Nat. Genet. – volume: 289 start-page: 747 year: 2014 end-page: 764 ident: CR51 article-title: De novo synthesis of steroids and oxysterols in adipocytes publication-title: J. Biol. Chem. – volume: 518 start-page: 187 year: 2015 end-page: 196 ident: CR1 article-title: New genetic loci link adipose and insulin biology to body fat distribution publication-title: Nature – volume: 115 start-page: 1529 year: 2018 end-page: 1534 ident: CR37 article-title: Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis publication-title: Proc. Natl Acad. Sci. USA – volume: 43 start-page: 1269 year: 2019 end-page: 1280 ident: CR36 article-title: Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity publication-title: Int. J. Obes. – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR49 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 117 start-page: 2362 year: 2007 end-page: 2368 ident: CR23 article-title: Angiogenesis modulates adipogenesis and obesity publication-title: J. Clin. Invest. – volume: 3 start-page: 10 year: 2016 ident: CR39 article-title: Relationships between rodent white adipose fat pads and human white adipose fat depots publication-title: Front. Nutr. – volume: 284 start-page: 450 year: 2018 end-page: 463 ident: CR2 article-title: Genes that make you fat, but keep you healthy publication-title: J. Intern. Med. – volume: 9 year: 2008 ident: CR42 article-title: WGCNA: an R package for weighted correlation network analysis publication-title: BMC Bioinform. – volume: 113 start-page: 147 year: 2003 end-page: 158 ident: CR34 article-title: Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis publication-title: Cell – volume: 49 start-page: 17 year: 1983 end-page: 26 ident: CR46 article-title: Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice publication-title: Br. J. Nutr. – volume: 11 start-page: e002162 year: 2018 ident: CR12 article-title: Large-scale phenome-wide association study of PCSK9 variants demonstrates protection against ischemic stroke publication-title: Circ. Genom. Precis. Med. – volume: 100 start-page: 428 year: 2017 end-page: 443 ident: CR19 article-title: Genetic regulation of adipose gene expression and cardio-metabolic traits publication-title: Am. J. Hum. Genet. – volume: 49 start-page: 17 year: 2017 end-page: 26 ident: CR4 article-title: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance publication-title: Nat. Genet. – volume: 11 start-page: e002162 year: 2018 ident: CR40 article-title: Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke publication-title: Circ Genom Precis Med – volume: 50 start-page: 572 year: 2018 end-page: 580 ident: CR18 article-title: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition publication-title: Nat. Genet. – volume: 5 start-page: e12677 year: 2016 ident: CR53 article-title: Nucleosomes impede Cas9 access to DNA in vivo and in vitro publication-title: Elife – volume: 7 start-page: e543 year: 2019 ident: CR8 article-title: High expression of FAM13A was associated with increasing the liver cirrhosis risk publication-title: Mol. Genet. Genom. Med. – volume: 1 start-page: 184 year: 2008 end-page: 189 ident: CR52 article-title: Human SGBS cells - a unique tool for studies of human fat cell biology publication-title: Obes. Facts – volume: 25 start-page: 8 year: 2001 end-page: 15 ident: CR17 article-title: Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation publication-title: Int J. Obes. Relat. Metab. Disord. – volume: 13 start-page: 397 year: 2014 end-page: 406 ident: CR9 article-title: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics publication-title: Mol. Cell Proteomics – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR48 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 42 start-page: 200 year: 2010 end-page: 202 ident: CR7 article-title: Variants in FAM13A are associated with chronic obstructive pulmonary disease publication-title: Nat. Genet. – volume: 5 start-page: e1000754 year: 2009 ident: CR16 article-title: Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the stockholm atherosclerosis gene expression (STAGE) study publication-title: PLOS Genet. – volume: 284 start-page: 450 year: 2018 ident: 15291_CR2 publication-title: J. Intern. Med. doi: 10.1111/joim.12827 – volume: 53 start-page: 2791 year: 2012 ident: 15291_CR45 publication-title: J. Lipid Res. doi: 10.1194/jlr.D023788 – volume: 45 start-page: 1274 year: 2013 ident: 15291_CR6 publication-title: Nat. Genet. doi: 10.1038/ng.2797 – volume: 61 start-page: 1112 year: 2018 ident: 15291_CR38 publication-title: Diabetologia doi: 10.1007/s00125-018-4572-8 – volume: 1 start-page: 184 year: 2008 ident: 15291_CR52 publication-title: Obes. Facts doi: 10.1159/000145784 – volume: 2 start-page: 196 year: 2016 ident: 15291_CR41 publication-title: Cell Syst. doi: 10.1016/j.cels.2016.02.002 – volume: 63 start-page: 4369 year: 2014 ident: 15291_CR5 publication-title: Diabetes doi: 10.2337/db14-0318 – volume: 99 start-page: 1245 year: 2016 ident: 15291_CR10 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2016.10.003 – volume: 8 year: 2017 ident: 15291_CR25 publication-title: Nat. Commun. – volume: 100 start-page: 428 year: 2017 ident: 15291_CR19 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2017.01.027 – volume: 55 start-page: 2622 year: 2012 ident: 15291_CR27 publication-title: Diabetologia doi: 10.1007/s00125-012-2639-5 – volume: 11 start-page: e002162 year: 2018 ident: 15291_CR40 publication-title: Circ Genom Precis Med – volume: 156 start-page: 20 year: 2014 ident: 15291_CR32 publication-title: Cell doi: 10.1016/j.cell.2013.12.012 – volume: 26 start-page: 1160 year: 2015 ident: 15291_CR43 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E14-08-1276 – volume: 2008 start-page: pdb prot4986 year: 2008 ident: 15291_CR44 publication-title: CSH Protoc. – volume: 49 start-page: 17 year: 2017 ident: 15291_CR4 publication-title: Nat. Genet. doi: 10.1038/ng.3714 – volume: 5 year: 2015 ident: 15291_CR26 publication-title: Sci. Rep. doi: 10.1038/srep14841 – volume: 115 start-page: 1529 year: 2018 ident: 15291_CR37 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1720475115 – volume: 289 start-page: 747 year: 2014 ident: 15291_CR51 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.534172 – volume: 20 start-page: 547 year: 2017 ident: 15291_CR24 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2017.01.010 – volume: 11 start-page: 1889 year: 2016 ident: 15291_CR15 publication-title: Nat. Protoc. doi: 10.1038/nprot.2016.117 – volume: 5 start-page: e1000754 year: 2009 ident: 15291_CR16 publication-title: PLOS Genet. doi: 10.1371/journal.pgen.1000754 – volume: 42 start-page: 200 year: 2010 ident: 15291_CR7 publication-title: Nat. Genet. doi: 10.1038/ng.535 – volume: 13 start-page: 397 year: 2014 ident: 15291_CR9 publication-title: Mol. Cell Proteomics doi: 10.1074/mcp.M113.035600 – volume: 9 start-page: 367 year: 2008 ident: 15291_CR28 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2391 – volume: 51 start-page: 646 year: 2014 ident: 15291_CR33 publication-title: J. Med. Genet. doi: 10.1136/jmedgenet-2014-102525 – volume: 7 start-page: e543 year: 2019 ident: 15291_CR8 publication-title: Mol. Genet. Genom. Med. doi: 10.1002/mgg3.543 – volume: 3 start-page: 10 year: 2016 ident: 15291_CR39 publication-title: Front. Nutr. doi: 10.3389/fnut.2016.00010 – volume: 43 start-page: 1269 year: 2019 ident: 15291_CR36 publication-title: Int. J. Obes. doi: 10.1038/s41366-018-0222-y – volume: 9 year: 2008 ident: 15291_CR42 publication-title: BMC Bioinform. doi: 10.1186/1471-2105-9-559 – volume: 26 start-page: 139 year: 2010 ident: 15291_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 11 start-page: e002162 year: 2018 ident: 15291_CR12 publication-title: Circ. Genom. Precis. Med. – volume: 268 start-page: 22243 year: 1993 ident: 15291_CR29 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)41516-5 – volume: 113 start-page: 147 year: 2003 ident: 15291_CR34 publication-title: Cell doi: 10.1016/S0092-8674(03)00271-X – volume: 29 start-page: 15 year: 2013 ident: 15291_CR48 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 44 start-page: 991 year: 2012 ident: 15291_CR3 publication-title: Nat. Genet. doi: 10.1038/ng.2385 – volume: 18 start-page: 1539 year: 2012 ident: 15291_CR30 publication-title: Nat. Med. doi: 10.1038/nm.2899 – volume: 12 start-page: 491 year: 2005 ident: 15291_CR50 publication-title: Am. J. Ther. doi: 10.1097/01.mjt.0000178781.89789.25 – volume: 13 start-page: e1007079 year: 2017 ident: 15291_CR13 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1007079 – volume: 276 start-page: 41245 year: 2001 ident: 15291_CR31 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M103241200 – volume: 58 start-page: 481 year: 2017 ident: 15291_CR14 publication-title: J. Lipid Res. doi: 10.1194/jlr.O072629 – volume: 159 start-page: 647 year: 2014 ident: 15291_CR54 publication-title: Cell doi: 10.1016/j.cell.2014.09.029 – volume: 518 start-page: 187 year: 2015 ident: 15291_CR1 publication-title: Nature doi: 10.1038/nature14132 – volume: 5 start-page: e12677 year: 2016 ident: 15291_CR53 publication-title: Elife doi: 10.7554/eLife.12677 – volume: 12 start-page: e1001779 year: 2015 ident: 15291_CR11 publication-title: PLoS Med. doi: 10.1371/journal.pmed.1001779 – volume: 49 start-page: 17 year: 1983 ident: 15291_CR46 publication-title: Br. J. Nutr. doi: 10.1079/BJN19830006 – volume: 6 start-page: 247ra103 year: 2014 ident: 15291_CR22 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3008490 – volume: 20 start-page: 16 year: 2009 ident: 15291_CR35 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2008.09.002 – volume: 125 start-page: 1739 year: 2015 ident: 15291_CR47 publication-title: J. Clin. Invest. doi: 10.1172/JCI74692 – volume: 25 start-page: 8 year: 2001 ident: 15291_CR17 publication-title: Int J. Obes. Relat. Metab. Disord. doi: 10.1038/sj.ijo.0801520 – volume: 31 start-page: 21 year: 2002 ident: 15291_CR20 publication-title: Nat. Genet. doi: 10.1038/ng880 – volume: 50 start-page: 572 year: 2018 ident: 15291_CR18 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0088-x – volume: 117 start-page: 2362 year: 2007 ident: 15291_CR23 publication-title: J. Clin. Invest. doi: 10.1172/JCI32239 – volume: 5 start-page: 491 year: 2016 ident: 15291_CR21 publication-title: Mol. Metab. doi: 10.1016/j.molmet.2016.05.004 |
| SSID | ssj0000391844 |
| Score | 2.506563 |
| Snippet | Genetic variation in the
FAM13A
(Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in... Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in... Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in... |
| SourceID | doaj swepub pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1465 |
| SubjectTerms | 13/106 13/51 13/89 49/105 49/39 631/208/191/2018 631/208/205 631/443/319/1642 64/60 692/163/2743/393 82/1 96/1 Adipocytes Adipocytes - metabolism Adipogenesis - genetics Adipose tissue Animals Anthropometry Body fat Body Fat Distribution Cell Differentiation - genetics Differentiation Gene Knockdown Techniques Gene mapping Genetic diversity Genetic Loci Genetic variance Genome-wide association studies Genome-Wide Association Study GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism HEK293 Cells High fat diet Hip Humanities and Social Sciences Humans In vivo methods and tests Insulin Insulin resistance Insulin Resistance - genetics Intra-Abdominal Fat - metabolism Loci Male Mapping Metabolism Metabolomics Mice, Inbred C57BL Mice, Knockout multidisciplinary Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Preadipocytes RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Size distribution Subcutaneous Fat - metabolism |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Ni9UwEA-yKHgRv62uEkFPWrb5alo8PT8eHnTxoLK3ME1TfCB9y74-4e1f70zSV7cq68VLoU1C0vnIzJDJbxh7hnKBhqPQuW7pUWrIwYQit1BAI0MXACJk_gd7fFydnNSfLpT6opywBA-cCHfUeNHiILSzGnRnFViUIEuoJWgItYyuUWHrC8FU3INVjaGLHm_JFKo62ui4J1C0hCarFvn5zBJFwP6_eZl_JktOJ6a_oYtGi7S8yW6MriRfpF-4xa6E_ja7lopL7u6wV8vFR6EWHFLGBm_W7Y53MPCWsHLHMlcc-pZDuzpd-90QOFk5-nyXfVm--_zmfT6WSsi9sXbIQaoyyBK8NiAa1dB1U-iK1kDT2aJWGjlV4psXRSeFbkVXStAW5_fowkmj7rGDft2HB4wHqVQJQVkKlQi4FozxFcYdBr3DKlQZE3uyOT_iiFM5i-8unmeryiVSOyS1i6R25xl7MY05TSgal_Z-TdyYehICdvyAcuFGuXD_kouMHe556Ua13DipbG0IEt9m7OnUjApFpyTQh_WW-lSixKDU6ozdT6yfVqJwf1eKWuxMKGZLnbf0q28RtNui74XuVcZe7sXn17IuI8XzJGKzGd6uvi4iMbZbR3hlQjz8HyR7xK5L0g_KVqwP2cFwtg2P2VX_Y1htzp5EBfsJNFIkmw priority: 102 providerName: Directory of Open Access Journals |
| Title | FAM13A affects body fat distribution and adipocyte function |
| URI | https://link.springer.com/article/10.1038/s41467-020-15291-z https://www.ncbi.nlm.nih.gov/pubmed/32193374 https://www.proquest.com/docview/2379539157 https://www.proquest.com/docview/2381624974 https://pubmed.ncbi.nlm.nih.gov/PMC7081215 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409711 https://doaj.org/article/bc1db2e1724a4f73a77947050955442a |
| Volume | 11 |
| WOSCitedRecordID | wos000522138100013&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDaS98D0IjCpI8ATR4o_EqXhAHawCiVURAlR4sS6JwyqhpLQpUvfX43PSTAXUF14sxXbkj7vzne3z7wCeWb6wiiOUgSwoiSUGGJkwUBhixk1pEB1k_gc1mSTT6TDtDtyWnVvlZk10C3VR53RGfsKFGkaEZq5ez38GFDWKble7EBp7cEAoCdy57qX9GQuhnydSdm9lQpGcLKVbGWjPZKsPWXC5pY8cbP-_bM2_XSb7e9M_MEadXhrf-t8R3YabnUXqj1oWugPXTHUXbrQxKtf34NV4dM7EyMfW8cPP6mLtl9j4BUHudtGyfKwKH4vZvM7XjfFJWVL2ffg8Pvv05l3QRVwI8kipJkAuYsNjzGWELBMZvVrFMiwizEoVDoW0BI_tV87CkjNZsDLmKJVtP7eWII_EEexXdWUegm-4EDEaoWjHRfi3GEV5YrcvkTUyE5N4wDbzrvMOjpyiYvzQ7lpcJLqllba00o5W-tKDF_0_8xaMY2ftUyJnX5OAtF1GvfiuO7nUWc4Ky5PWjJMoSyVQ2QVKESiOtbMkRw-ON8TTnXQv9RXlPHjaF1u5pMsWrEy9ojoJi-3eVkkPHrS80_dEWDUhBJWoLa7a6up2STW7cNjfyppwltM9eLnhv6tu7ZqK5y2PbrXwdvZl5CZjtdIEe8bYo92jfQyHnESH3BmHx7DfLFbmCVzPfzWz5WIAe2qqXJoM4OD0bJJ-HLgjjoGTSpum0Tdbkr4_T7_-BhbUOuo |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9NAFB5VKQgu7IuhgJHoCax6FnscIYQCJWrUJMqhoPY0PNtjiITskAWU_ih-I-95qwIotx64WPLMWB6Pv7fN8j3GXiAu0HD4ylMpXUIFHgTW9zT4EAubWYCSMn-ox-Po9LQ72WG_mrMwtK2y0Ymlok6LhObID4TU3YDYzPXb2XePskbR6mqTQqOCxbFd_8SQbfFmcIj_d1-I_oeT90denVXASwKtlx4IGVoRQqIC4LGM6WQmZH4aQJxpjO8VflSIdwn3M8FVyrNQgNIZFqO3IyhLBKr8XUVg77DdyWA0OWtndYhvPVKqPp3jy-hgoUpdRFEamsou9843LGCZKOBf3u3fmzTbldo_WE1LS9i_-b-N4S12o_a53V4lJLfZjs3vsKtVFs71Xfa63xtx2XOh2trixkW6djNYuimRCtf5wFzIUxfS6axI1kvrkjtAxffYx0vp-X3WyYvcPmSuFVKGYKWmmJIYfiEIkggDtADd6MhGDuPNfzZJTbhOeT--mXLhX0amwoZBbJgSG-bcYS_bZ2YV3cjW1u8IPm1LogovC4r5F1NrHhMnPEWpQ0dVgcq0BI0qWBPtD3qSSoDD9hqwmFp_LcwFUhz2vK1GzUPLSZDbYkVtIh5i9K6Vwx5UWG17ItEQSkk1egPFG13drMmnX0t2c41OKvqhDnvV4P2iW9uGYr-SiY03HE4_9crBWK0MEbtx_mj71z5j145ORkMzHIyPH7PrgsSWNm9291hnOV_ZJ-xK8mM5Xcyf1pLvss-XLSi_AY5Ak2k |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jj9MwFLZGwyIu7EtggCAxJ4gaL4lTIYQKpWI0Q9UDoNFczEviQCWUlC6gzk_j1_Ges4wKqLc5cKkU21Ed53tb_Pw9xp4iLtBwhCpQOf3ECgKIbBhoCCEVtrAAjjL_SI_HyfFxf7LDfrVnYSitstWJTlHnVUbfyHtC6n5EbOa6VzRpEZPh6NXse0AVpGintS2nUUPk0K5_Yvi2eHkwxHe9L8To7Yc374KmwkCQRVovAxAytiKGTEXAU5nSKU0owjyCtNAY6yt8wBivMh4WgqucF7EApQtsRs9HUMUIVP8XNMaYlE44iU667zvEvJ4o1ZzTCWXSWyinlSheQ6PZ58Hphi10JQP-5ef-na7Z7dn-wW_qbOLo2v-8mtfZ1cYT9we16NxgO7a8yS7VtTnXt9iL0eA9lwMf6oQXP63ytV_A0s-JaripEuZDmfuQT2dVtl5an5wEar7NPp7LzO-w3bIq7T3mWyFlDFZqijSJ9xeiKEswbIvQuU5s4jHevnOTNTTsVA3km3HpADIxNU4M4sQ4nJhTjz3r7pnVJCRbR78mKHUjiUDcNVTzL6bRRybNeI6yiO6rAlVoCRoVsyYyIPQvlQCP7bXAMY1WW5gz1HjsSdeN-og2maC01YrGJDzGmF4rj92tcdvNRKJ5lJJ69AaiN6a62VNOvzrOc42uK3qnHnveYv9sWtuWYr-Wj41_GE4_DdxirFaG6N44v7_9aR-zyygd5uhgfPiAXREkwZTR2d9ju8v5yj5kF7Mfy-li_sipAJ99Pm8p-Q2e0ZrM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=FAM13A+affects+body+fat+distribution+and+adipocyte+function&rft.jtitle=Nature+communications&rft.au=Fathzadeh%2C+Mohsen&rft.au=Li%2C+Jiehan&rft.au=Rao%2C+Abhiram&rft.au=Cook%2C+Naomi&rft.date=2020-03-19&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-020-15291-z&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_020_15291_z |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |