Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) Jg. 153; H. 1; S. 59
Hauptverfasser: Dietz, Allan B, Dozois, Eric J, Fletcher, Joel G, Butler, Greg W, Radel, Darcie, Lightner, Amy L, Dave, Maneesh, Friton, Jessica, Nair, Asha, Camilleri, Emily T, Dudakovic, Amel, van Wijnen, Andre J, Faubion, William A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.07.2017
Schlagworte:
Absorbable Implants - adverse effects
Adolescent
Adult
Crohn Disease - complications
Cutaneous Fistula - etiology
Cutaneous Fistula - therapy
Female
Humans
Male
Mesenchymal Stem Cell Transplantation - adverse effects
Middle Aged
Rectal Fistula - etiology
Rectal Fistula - therapy
Transplantation, Autologous
Treatment Outcome
Wound Healing
Young Adult
IBD
Cell Therapy
Clinical Trial
STOMP Trial
ISSN:1528-0012, 1528-0012
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.
AbstractList In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.
In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.
Author Fletcher, Joel G
Dave, Maneesh
Butler, Greg W
Lightner, Amy L
Dietz, Allan B
Faubion, William A
Friton, Jessica
Dozois, Eric J
Camilleri, Emily T
Radel, Darcie
Nair, Asha
Dudakovic, Amel
van Wijnen, Andre J
Author_xml – sequence: 1
  givenname: Allan B
  surname: Dietz
  fullname: Dietz, Allan B
  email: dietz.allan@mayo.edu
  organization: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: dietz.allan@mayo.edu
– sequence: 2
  givenname: Eric J
  surname: Dozois
  fullname: Dozois, Eric J
  organization: Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota
– sequence: 3
  givenname: Joel G
  surname: Fletcher
  fullname: Fletcher, Joel G
  organization: Department of Radiology, Mayo Clinic, Rochester, Minnesota
– sequence: 4
  givenname: Greg W
  surname: Butler
  fullname: Butler, Greg W
  organization: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
– sequence: 5
  givenname: Darcie
  surname: Radel
  fullname: Radel, Darcie
  organization: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
– sequence: 6
  givenname: Amy L
  surname: Lightner
  fullname: Lightner, Amy L
  organization: Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota
– sequence: 7
  givenname: Maneesh
  surname: Dave
  fullname: Dave, Maneesh
  organization: Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio
– sequence: 8
  givenname: Jessica
  surname: Friton
  fullname: Friton, Jessica
  organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
– sequence: 9
  givenname: Asha
  surname: Nair
  fullname: Nair, Asha
  organization: Department of Biomedical Statistics and Information, Mayo Clinic, Rochester, Minnesota
– sequence: 10
  givenname: Emily T
  surname: Camilleri
  fullname: Camilleri, Emily T
  organization: Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
– sequence: 11
  givenname: Amel
  surname: Dudakovic
  fullname: Dudakovic, Amel
  organization: Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
– sequence: 12
  givenname: Andre J
  surname: van Wijnen
  fullname: van Wijnen, Andre J
  organization: Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
– sequence: 13
  givenname: William A
  surname: Faubion
  fullname: Faubion, William A
  email: faubion.william@mayo.edu
  organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: faubion.william@mayo.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28400193$$D View this record in MEDLINE/PubMed
BookMark eNpNkMFKxDAQhoMo6q6-gUhuenBr0jZNelxXV4VdFFQ8lmk73Y20zZqkoI_gWxtxBS8zPzP_fDD_iOz2pkdCTjiLOBPJ5Vu0AuetiWLGZcTSiDG-Qw65iNUkyHj3nz4gI-feGGN5ovg-OYhVGsZ5cki-poM3rVmZwdElOuyr9WcHLX3y2NEZtq27oNPNptVYU91ToFfaQOmMLaFskS7BW_1xQRtj6bNF8B32npqGPqLV0AfQXDs_tOB-rh_B67B39FX7NZ1Zs-7PHL3WDsHhEdlroHV4vO1j8jK_eZ7dTRYPt_ez6WJSCcn9BDCtmqSJa15xyBFVVmclKMlUU9aiLmVeNyBEkwopcqUgyULNEl5lUlaygnhMzn-5G2veB3S-6LSrwqfQY0ih4CrARJwJGaynW-tQdlgXG6s7sJ_FX3zxNwtYdxk
CitedBy_id crossref_primary_10_1016_j_trim_2023_101903
crossref_primary_10_1177_2040622319899297
crossref_primary_10_1016_j_arcmed_2025_103212
crossref_primary_10_1089_scd_2023_0273
crossref_primary_10_1016_j_dld_2019_11_016
crossref_primary_10_1080_17474124_2018_1480936
crossref_primary_10_1111_codi_14054
crossref_primary_10_1007_s43472_020_00026_8
crossref_primary_10_2217_imt_2018_0099
crossref_primary_10_1016_j_jcyt_2025_01_013
crossref_primary_10_1016_j_jcyt_2023_01_014
crossref_primary_10_1097_DCR_0000000000002567
crossref_primary_10_1080_17474124_2020_1764349
crossref_primary_10_14309_ajg_0000000000002326
crossref_primary_10_1007_s10620_017_4645_4
crossref_primary_10_1093_ecco_jcc_jjac172
crossref_primary_10_1007_s10620_022_07722_2
crossref_primary_10_1093_crocol_otz025
crossref_primary_10_1093_stmcls_sxae040
crossref_primary_10_4274_tjcd_galenos_2021_2021_10_6
crossref_primary_10_1016_j_mayocp_2019_03_013
crossref_primary_10_4236_ojped_2025_155071
crossref_primary_10_1007_s10151_020_02359_7
crossref_primary_10_1080_14712598_2019_1623876
crossref_primary_10_1155_2018_9652817
crossref_primary_10_1097_DCR_0000000000001924
crossref_primary_10_2147_JIR_S458103
crossref_primary_10_1177_15533506231157167
crossref_primary_10_1111_cts_13821
crossref_primary_10_1007_s12664_024_01524_2
crossref_primary_10_1007_s40472_019_00238_1
crossref_primary_10_1002_sctm_21_0021
crossref_primary_10_1016_j_gene_2020_144437
crossref_primary_10_2147_CEG_S434014
crossref_primary_10_1097_DCR_0000000000001093
crossref_primary_10_4103_1673_5374_303031
crossref_primary_10_1038_ncb3635
crossref_primary_10_1093_ecco_jcc_jjaa009
crossref_primary_10_1080_08923973_2018_1469144
crossref_primary_10_1007_s40259_024_00661_6
crossref_primary_10_1053_j_gastro_2019_09_057
crossref_primary_10_1053_j_gastro_2019_04_031
crossref_primary_10_1093_ecco_jcc_jjy226
crossref_primary_10_1093_ibd_izy084
crossref_primary_10_1186_s13287_021_02613_1
crossref_primary_10_3390_medicina56110563
crossref_primary_10_1002_lt_25682
crossref_primary_10_1016_j_hsr_2022_100026
crossref_primary_10_1089_lap_2021_0285
crossref_primary_10_1080_17474124_2022_2036122
crossref_primary_10_1088_1758_5090_ac0982
crossref_primary_10_1093_ibd_izz215
crossref_primary_10_1016_j_giec_2019_02_011
crossref_primary_10_1097_DCR_0000000000002579
crossref_primary_10_1186_s13287_020_02095_7
crossref_primary_10_1136_gutjnl_2017_314918
crossref_primary_10_1186_s13287_022_02811_5
crossref_primary_10_1053_j_gastro_2019_05_078
crossref_primary_10_1136_annrheumdis_2018_214024
crossref_primary_10_1002_jbm4_10520
crossref_primary_10_1093_ibd_izad100
crossref_primary_10_3748_wjg_v27_i25_3693
crossref_primary_10_1007_s10151_019_01994_z
crossref_primary_10_1016_j_biomaterials_2023_122099
crossref_primary_10_1002_jgh3_12141
crossref_primary_10_1016_j_jcol_2018_03_004
crossref_primary_10_3390_life11111133
crossref_primary_10_1186_s12893_023_01912_z
crossref_primary_10_1007_s40267_018_0549_4
crossref_primary_10_3389_fphar_2018_00179
crossref_primary_10_1080_14712598_2018_1492543
crossref_primary_10_3390_ijms231710023
crossref_primary_10_1016_j_jcyt_2017_12_004
crossref_primary_10_1016_j_surg_2023_07_020
crossref_primary_10_1007_s12015_022_10353_9
crossref_primary_10_1093_ibd_izab151
crossref_primary_10_1016_j_jcyt_2017_12_001
crossref_primary_10_2147_JIR_S400447
crossref_primary_10_1002_cbin_11943
crossref_primary_10_1097_MOT_0000000000000586
crossref_primary_10_1186_s13287_021_02692_0
crossref_primary_10_1016_j_tice_2025_103041
crossref_primary_10_1007_s10529_021_03207_w
crossref_primary_10_1097_DCR_0000000000002473
crossref_primary_10_12998_wjcc_v6_i12_493
crossref_primary_10_1007_s10151_019_02024_8
crossref_primary_10_1007_s13577_021_00578_0
crossref_primary_10_1155_2020_8816737
crossref_primary_10_3390_ijms22189967
crossref_primary_10_1097_DCR_0000000000001700
crossref_primary_10_3390_biom11010082
crossref_primary_10_1053_j_gastro_2019_01_032
crossref_primary_10_3390_cells8070764
crossref_primary_10_4252_wjsc_v17_i8_107639
crossref_primary_10_1097_MOG_0000000000000545
crossref_primary_10_1007_s11725_017_0728_9
crossref_primary_10_1093_ecco_jcc_jjz187
crossref_primary_10_1002_iid3_70189
crossref_primary_10_3389_fmed_2021_765474
crossref_primary_10_1093_gastro_goac085
crossref_primary_10_1080_00914037_2021_1999955
crossref_primary_10_1002_ags3_12177
crossref_primary_10_1093_ecco_jcc_jjae089
crossref_primary_10_5500_wjt_v8_i4_97
crossref_primary_10_1016_j_phrs_2020_105247
crossref_primary_10_2174_1381612825666190308095651
crossref_primary_10_1186_s13148_020_00843_3
crossref_primary_10_1097_DCR_0000000000001333
crossref_primary_10_1053_j_gastro_2019_02_005
crossref_primary_10_1007_s40265_017_0842_x
crossref_primary_10_1016_j_giec_2022_05_001
crossref_primary_10_1007_s11894_019_0672_y
crossref_primary_10_1093_ibd_izad195
crossref_primary_10_1016_j_surg_2023_11_007
crossref_primary_10_1080_14712598_2024_2383882
crossref_primary_10_3389_fcell_2022_867426
crossref_primary_10_4252_wjsc_v12_i10_1050
crossref_primary_10_1007_s10151_025_03138_y
crossref_primary_10_1016_S1875_5364_22_60176_6
crossref_primary_10_1007_s00441_022_03616_x
crossref_primary_10_1016_S0246_0424_24_48137_5
crossref_primary_10_1038_nrgastro_2017_104
crossref_primary_10_1016_j_jcyt_2020_12_013
crossref_primary_10_1016_j_jcyt_2020_12_012
crossref_primary_10_1016_j_suc_2019_08_012
crossref_primary_10_1093_ibd_izy329
crossref_primary_10_1016_j_addr_2021_113841
crossref_primary_10_1007_s00508_023_02283_4
crossref_primary_10_1002_sctm_20_0146
crossref_primary_10_1002_mba2_70022
crossref_primary_10_1016_j_suc_2024_09_007
ContentType Journal Article
Copyright Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1053/j.gastro.2017.04.001
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
EISSN 1528-0012
ExternalDocumentID 28400193
Genre Clinical Trial, Phase I
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: R01 AI089714
– fundername: NIDDK NIH HHS
  grantid: P30 DK097948
GroupedDBID ---
--K
.1-
.55
.FO
.GJ
0R~
1B1
1CY
1P~
1~5
3O-
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
AAEDT
AAEDW
AAIKJ
AALRI
AAQFI
AAQOH
AAQQT
AAQXK
AAXUO
AAYOK
ABCQX
ABDPE
ABJNI
ABLJU
ABMAC
ABOCM
ABWVN
ACRPL
ADBBV
ADMUD
ADNMO
ADPAM
AENEX
AEVXI
AFCTW
AFFNX
AFHKK
AFJKZ
AFRHN
AFTJW
AGHFR
AI.
AITUG
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BELOY
BR6
C5W
CAG
CGR
COF
CS3
CUY
CVF
DU5
EBS
ECM
EFJIC
EIF
EJD
F5P
FD8
FDB
FEDTE
FGOYB
GBLVA
HVGLF
HZ~
IHE
J1W
J5H
K-O
KOM
L7B
M41
MO0
N4W
N9A
NPM
NQ-
O9-
OC.
OHT
ON0
P2P
PC.
PKN
QTD
R2-
RIG
ROL
RPZ
SEL
SES
SJN
SSZ
UDS
UGJ
UV1
VH1
WH7
X7M
XH2
Y6R
YQJ
Z5R
ZGI
ZXP
7X8
AAFWJ
ACVFH
ADCNI
EFKBS
ID FETCH-LOGICAL-c571t-ae4cf3f2d1c1a9ee86d6ba8708fbd5db79dfa55f4575988a36988631c677c7ca2
IEDL.DBID 7X8
ISICitedReferencesCount 145
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000403918300024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1528-0012
IngestDate Sun Sep 28 00:02:10 EDT 2025
Wed Feb 19 02:36:09 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords IBD
Cell Therapy
Clinical Trial
STOMP Trial
Language English
License Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c571t-ae4cf3f2d1c1a9ee86d6ba8708fbd5db79dfa55f4575988a36988631c677c7ca2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/5484717
PMID 28400193
PQID 1887052657
PQPubID 23479
ParticipantIDs proquest_miscellaneous_1887052657
pubmed_primary_28400193
PublicationCentury 2000
PublicationDate 2017-07-01
PublicationDateYYYYMMDD 2017-07-01
PublicationDate_xml – month: 07
  year: 2017
  text: 2017-07-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Gastroenterology (New York, N.Y. 1943)
PublicationTitleAlternate Gastroenterology
PublicationYear 2017
SSID ssj0009381
Score 2.5984657
Snippet In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 59
SubjectTerms Absorbable Implants - adverse effects
Adolescent
Adult
Crohn Disease - complications
Cutaneous Fistula - etiology
Cutaneous Fistula - therapy
Female
Humans
Male
Mesenchymal Stem Cell Transplantation - adverse effects
Middle Aged
Rectal Fistula - etiology
Rectal Fistula - therapy
Transplantation, Autologous
Treatment Outcome
Wound Healing
Young Adult
Title Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/28400193
https://www.proquest.com/docview/1887052657
Volume 153
WOSCitedRecordID wos000403918300024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JTsMwELXYhLiw74uMhMSF0AbXcXJCUKi4pIoEiN4qxwsNKklpUgSfwF8zk6TihITExTfHjj0ev_HMvCHkJLBg6hjOHAmXr9NS2nN838aOsB5zZdNya2RZbEJ0u36vF0T1g1teh1VOdWKpqHWm8I284cJpQG4SLi5Hbw5WjULval1CY5bMM4AyGNIlej9s4QHzK75UZGEGTTxNneOs8XL-LPNijOl_rijJTpvu7yCzvGw6K_-d5ipZrmEmvarkYo3MmHSdLIa1I32DfF1NysK1YPfTEBOQ1ODzFTrcF-aVts1wmJ_RGqDSJKWSXieZjPNsHGOqFQ2R2P_jjALipQ_TUHWaWRqhQOPIHRCfCSBz7B1V3K05fUqKAW2Ps0F6mtObyjW0SR47tw_tO6euyuAoLtzCkaalLLMX2lWuDIzxPe3FEv4atlhzHYtAW8m5bWHpT9-XzIMWNl55Qiih5MUWmUuz1OwQGqiAgRIJuAKjsMklfEVorxXDQGBlWr1LjqeL3AepR1eGTA2sTP9nmXfJdrVT_VFFz9GHCxeBK9v7Q-99soQCUMXfHpB5C2feHJIF9V4k-fioFCdou1H4Dcym1hM
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Autologous+Mesenchymal+Stem+Cells%2C+Applied+in+a+Bioabsorbable+Matrix%2C+for+Treatment+of+Perianal+Fistulas+in+Patients+With+Crohn%27s+Disease&rft.jtitle=Gastroenterology+%28New+York%2C+N.Y.+1943%29&rft.au=Dietz%2C+Allan+B&rft.au=Dozois%2C+Eric+J&rft.au=Fletcher%2C+Joel+G&rft.au=Butler%2C+Greg+W&rft.date=2017-07-01&rft.eissn=1528-0012&rft.volume=153&rft.issue=1&rft.spage=59&rft_id=info:doi/10.1053%2Fj.gastro.2017.04.001&rft_id=info%3Apmid%2F28400193&rft_id=info%3Apmid%2F28400193&rft.externalDocID=28400193
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1528-0012&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1528-0012&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1528-0012&client=summon