Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associat...

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Bibliographic Details
Published in:Gastroenterology (New York, N.Y. 1943) Vol. 153; no. 1; p. 59
Main Authors: Dietz, Allan B, Dozois, Eric J, Fletcher, Joel G, Butler, Greg W, Radel, Darcie, Lightner, Amy L, Dave, Maneesh, Friton, Jessica, Nair, Asha, Camilleri, Emily T, Dudakovic, Amel, van Wijnen, Andre J, Faubion, William A
Format: Journal Article
Language:English
Published: United States 01.07.2017
Subjects:
Absorbable Implants - adverse effects
Adolescent
Adult
Crohn Disease - complications
Cutaneous Fistula - etiology
Cutaneous Fistula - therapy
Female
Humans
Male
Mesenchymal Stem Cell Transplantation - adverse effects
Middle Aged
Rectal Fistula - etiology
Rectal Fistula - therapy
Transplantation, Autologous
Treatment Outcome
Wound Healing
Young Adult
IBD
Cell Therapy
Clinical Trial
STOMP Trial
ISSN:1528-0012, 1528-0012
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Summary:In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.
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ISSN:1528-0012
1528-0012
DOI:10.1053/j.gastro.2017.04.001