MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

The vagus nerve can control inflammatory response through a ＇cholinergic anti-inflammatory pathway＇, which is mediated by the α7-nicotinic acetylcholine receptor （α7nAChR） on macrophages. However, the intracellular mechanisms that link a7nAChR activation and pro-inflammatory cytokine production rema...

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Bibliographic Details
Published in:	Cell research Vol. 23; no. 11; pp. 1270 - 1283
Main Authors:	Sun, Yang, Li, Qi, Gui, Huan, Xu, Dong-Ping, Yang, Yi-Li, Su, Ding-Feng, Liu, Xia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2013 Nature Publishing Group
Subjects:	631/250/127 631/250/2504/342 631/250/256 631/337/384/331 Acetylcholine receptors ADAM Proteins - metabolism ADAM17 Protein alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Biomedical and Life Sciences Cell Biology Cells, Cultured Cholinergic Neurons - metabolism Cytokines - biosynthesis Cytokines - genetics Cytokines - secretion HEK293 Cells Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Life Sciences Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL MicroRNAs - metabolism Original original-article Sepsis - chemically induced Sepsis - genetics Sepsis - metabolism Sepsis - pathology siRNA STAT3 STAT3 Transcription Factor - metabolism TNF-α Transcription, Genetic Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics 乙酰胆碱受体介导抗炎作用细胞因子胆碱能 macrophages septic shock α7nAChR cholinergic anti-inflammatory action STAT3 TACE micorRNA-124
ISSN:	1001-0602, 1748-7838, 1748-7838
Online Access:	Get full text
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