FANCD2 limits replication stress and genome instability in cells lacking BRCA2

Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled replication forks to maintain genome stability and promote cell survival. The tumor suppressor BRCA2 plays a key role in genome integrity by promoting...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 23; H. 8; S. 755 - 757
Hauptverfasser:	Michl, Johanna, Zimmer, Jutta, Buffa, Francesca M, McDermott, Ultan, Tarsounas, Madalena
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.08.2016 Nature Publishing Group
Schlagworte:	13 13/2 631/337/1427 631/67/1244 Antineoplastic Agents - pharmacology Biochemistry Biological Microscopy BRCA2 protein BRCA2 Protein - metabolism Breast cancer brief-communication Cancer Cancer cells Cell Line, Tumor Cell Survival DNA Damage DNA repair DNA Replication Fanconi Anemia Complementation Group D2 Protein - physiology Fanconi syndrome Fanconi's anemia Genetic aspects Genetic research Genome, Human Genomes Genomic Instability HEK293 Cells Homologous recombination Humans Life Sciences Membrane Biology Phthalazines - pharmacology Piperazines - pharmacology Protein Structure Replication Structure Tumor suppressor genes United Kingdom
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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