Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species...

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Bibliographic Details
Published in:Renal failure Vol. 45; no. 1; p. 2146512
Main Authors: Ma, Xiaoju, Ma, Jingru, Leng, Tian, Yuan, Zhongzhu, Hu, Tingting, Liu, Qiuyan, Shen, Tao
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.12.2023
Taylor & Francis Ltd
Taylor & Francis Group
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Apoptosis
Autophagy
Diabetes
Diabetes Mellitus
Diabetic kidney disease (DKD)
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - etiology
End-stage renal disease
Endothelial cells
Fibrosis
Glycosides
Humans
Kidney - pathology
Kidney diseases
MAP kinase
Medicine, Chinese Traditional
NF-κB protein
Oxidation
Oxidative Stress
Pathogenesis
Phosphatidylinositol 3-Kinases - metabolism
Protein kinase C
Reactive oxygen species
Review
State-of-the-Art Review
Traditional Chinese medicine
Transforming growth factor-b1
pathogenesis
Diabetic kidney disease (DKD)
traditional Chinese medicine
oxidative stress
ISSN:0886-022X, 1525-6049, 1525-6049
Online Access:Get full text
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Summary:Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species (ROS) via the polyol, PKC, AGE/RAGE and hexosamine pathways, resulting in enhanced oxidative stress response. In this way, pathways such as PI3K/Akt, TGF-β1/p38-MAPK and NF-κB are activated, inducing endothelial cell apoptosis, inflammation, autophagy and fibrosis that cause histologic and functional abnormalities of the kidney and finally result in kidney injury. Presently, the treatment for DKD remains an unresolved issue. Traditional Chinese medicine (TCM) has unique advantages for DKD prevention and treatment attributed to its multi-target, multi-component, and multi-pathway characteristics. Numerous studies have proved that Chinese herbs (e.g., Golden Thread, Kudzuvine Root, Tripterygium glycosides, and Ginseng) and patent medicines (e.g., Shenshuaining Tablet, Compound Rhizoma Coptidis Capsule, and Zishen Tongluo Granule) are effective for DKD treatment. The present review described the role of oxidative stress in DKD pathogenesis and the effect of TCM intervention for DKD prevention and treatment, in an attempt to provide evidence for clinical practice.
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These authors contributed equally to this work.
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2022.2146512