Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Renal failure Jg. 45; H. 1; S. 2146512
Hauptverfasser:	Ma, Xiaoju, Ma, Jingru, Leng, Tian, Yuan, Zhongzhu, Hu, Tingting, Liu, Qiuyan, Shen, Tao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Taylor & Francis 01.12.2023 Taylor & Francis Ltd Taylor & Francis Group
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Autophagy Diabetes Diabetes Mellitus Diabetic kidney disease (DKD) Diabetic Nephropathies - drug therapy Diabetic Nephropathies - etiology End-stage renal disease Endothelial cells Fibrosis Glycosides Humans Kidney - pathology Kidney diseases MAP kinase Medicine, Chinese Traditional NF-κB protein Oxidation Oxidative Stress Pathogenesis Phosphatidylinositol 3-Kinases - metabolism Protein kinase C Reactive oxygen species Review State-of-the-Art Review Traditional Chinese medicine Transforming growth factor-b1 pathogenesis Diabetic kidney disease (DKD) traditional Chinese medicine oxidative stress
ISSN:	0886-022X, 1525-6049, 1525-6049
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species (ROS) via the polyol, PKC, AGE/RAGE and hexosamine pathways, resulting in enhanced oxidative stress response. In this way, pathways such as PI3K/Akt, TGF-β1/p38-MAPK and NF-κB are activated, inducing endothelial cell apoptosis, inflammation, autophagy and fibrosis that cause histologic and functional abnormalities of the kidney and finally result in kidney injury. Presently, the treatment for DKD remains an unresolved issue. Traditional Chinese medicine (TCM) has unique advantages for DKD prevention and treatment attributed to its multi-target, multi-component, and multi-pathway characteristics. Numerous studies have proved that Chinese herbs (e.g., Golden Thread, Kudzuvine Root, Tripterygium glycosides, and Ginseng) and patent medicines (e.g., Shenshuaining Tablet, Compound Rhizoma Coptidis Capsule, and Zishen Tongluo Granule) are effective for DKD treatment. The present review described the role of oxidative stress in DKD pathogenesis and the effect of TCM intervention for DKD prevention and treatment, in an attempt to provide evidence for clinical practice.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work.
ISSN:	0886-022X 1525-6049 1525-6049
DOI:	10.1080/0886022X.2022.2146512