Modeling of freezing step during freeze-drying of drugs in vials

A mathematical model that simulates temperature profiles during freezing process of standard pharmaceutical formulations (mannitol and BSA based) was set up in two‐dimensional axsymmetric space, and the ice crystal mean sizes were semi empirically estimated from the resulting temperature profiles. W...

Full description

Saved in:

Bibliographic Details
Published in:	AIChE journal Vol. 53; no. 5; pp. 1362 - 1372
Main Authors:	Nakagawa, Kyuya, Hottot, Aurélie, Vessot, Séverine, Andrieu, Julien
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2007 Wiley Subscription Services American Institute of Chemical Engineers Wiley
Subjects:	Applied sciences Chemical and Process Engineering Chemical engineering Chemical Sciences Drugs Engineering Sciences Exact sciences and technology Freeze drying Freezing freezing modeling Heat and mass transfer. Packings, plates Ice ice crystal morphology Mass transfer Mathematical models nucleation temperature Sublimation Temperature Water vapor Temperature distribution Freeze drying Cooling nucleation temperature Sublimation ice crystal morphology Permeability Water vapor Modeling Freezing Mass transfer freeze-drying freezing modeling Mathematical model Crystal morphology Drying
ISSN:	0001-1541, 1547-5905
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!