Modeling of freezing step during freeze-drying of drugs in vials

A mathematical model that simulates temperature profiles during freezing process of standard pharmaceutical formulations (mannitol and BSA based) was set up in two‐dimensional axsymmetric space, and the ice crystal mean sizes were semi empirically estimated from the resulting temperature profiles. W...

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Bibliographic Details
Published in:AIChE journal Vol. 53; no. 5; pp. 1362 - 1372
Main Authors: Nakagawa, Kyuya, Hottot, Aurélie, Vessot, Séverine, Andrieu, Julien
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2007
Wiley Subscription Services
American Institute of Chemical Engineers
Wiley
Subjects:
Applied sciences
Chemical and Process Engineering
Chemical engineering
Chemical Sciences
Drugs
Engineering Sciences
Exact sciences and technology
Freeze drying
Freezing
freezing modeling
Heat and mass transfer. Packings, plates
Ice
ice crystal morphology
Mass transfer
Mathematical models
nucleation temperature
Sublimation
Temperature
Water vapor
Temperature distribution
Freeze drying
Cooling
nucleation temperature
Sublimation
ice crystal morphology
Permeability
Water vapor
Modeling
Freezing
Mass transfer
freeze-drying
freezing modeling
Mathematical model
Crystal morphology
Drying
ISSN:0001-1541, 1547-5905
Online Access:Get full text
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Summary:A mathematical model that simulates temperature profiles during freezing process of standard pharmaceutical formulations (mannitol and BSA based) was set up in two‐dimensional axsymmetric space, and the ice crystal mean sizes were semi empirically estimated from the resulting temperature profiles. Water vapor mass transfer permeability values during sublimation step were also estimated from ice phase morphological parameters. All these numerical data were compared with experimental data, and a quite good agreement was observed that confirmed the adequacy of the present model calculations. It was confirmed that, for a given formulation, the mass transfer parameters during freeze‐drying were strongly dependent on morphological textural parameters, and consequently, on the nucleation temperatures that fix the ice phase morphology. The influence of freezing rate was also predicted from the simulations, proving that an increase of cooling rates led to slower primary drying rates. © 2007 American Institute of Chemical Engineers AIChE J, 2007
Bibliography:ark:/67375/WNG-6RQVPQN8-3
istex:5195C0A842BB86D34ED46C9208BE5CE11CE06214
ArticleID:AIC11147
Japan Society for the Promotion of Science
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-2
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ISSN:0001-1541
1547-5905
DOI:10.1002/aic.11147