Modeling of freezing step during freeze-drying of drugs in vials

A mathematical model that simulates temperature profiles during freezing process of standard pharmaceutical formulations (mannitol and BSA based) was set up in two‐dimensional axsymmetric space, and the ice crystal mean sizes were semi empirically estimated from the resulting temperature profiles. W...

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Vydané v:	AIChE journal Ročník 53; číslo 5; s. 1362 - 1372
Hlavní autori:	Nakagawa, Kyuya, Hottot, Aurélie, Vessot, Séverine, Andrieu, Julien
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2007 Wiley Subscription Services American Institute of Chemical Engineers Wiley
Predmet:	Applied sciences Chemical and Process Engineering Chemical engineering Chemical Sciences Drugs Engineering Sciences Exact sciences and technology Freeze drying Freezing freezing modeling Heat and mass transfer. Packings, plates Ice ice crystal morphology Mass transfer Mathematical models nucleation temperature Sublimation Temperature Water vapor Temperature distribution Freeze drying Cooling nucleation temperature Sublimation ice crystal morphology Permeability Water vapor Modeling Freezing Mass transfer freeze-drying freezing modeling Mathematical model Crystal morphology Drying
ISSN:	0001-1541, 1547-5905
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