Regional variation in angiotensin converting enzyme activity in the human placenta

Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE activity/mg protein at 8-9 sites between the cord i...

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Vydané v:	Placenta (Eastbourne) Ročník 32; číslo 11; s. 906 - 908
Hlavní autori:	Brameld, J.M., Hold, R., Broughton Pipkin, F.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ltd 01.11.2011 Elsevier
Predmet:	Angiotensin converting enzyme Angiotensin II Biological and medical sciences Birth Weight - physiology Embryology: invertebrates and vertebrates. Teratology Embryonic Development - physiology Enzyme Activation Female Fundamental and applied biological sciences. Psychology Gestational Age human Humans Hypertension, Pregnancy-Induced - metabolism Infant, Newborn Internal Medicine Obesity - complications Obesity - metabolism Obesity - pathology Obstetrics and Gynecology Organ Size Peptidyl-Dipeptidase A - metabolism Peptidyl-Dipeptidase A - physiology Placenta Placenta - anatomy & histology Placenta - enzymology Placenta - metabolism Placenta - pathology placenta:birthweight ratio Placental size Pregnancy Pregnancy Complications - metabolism Pregnancy Complications - pathology Sampling site Tissue Distribution Umbilical Cord - anatomy & histology Umbilical Cord - pathology Sampling site Placenta Angiotensin converting enzyme Placental size placenta:birthweight ratio Angiotensin II human Human Peptidases Vertebrata Mammalia Fetal membrane Enzyme Peptidyl-dipeptidase A Hydrolases Peptidyl-dipeptidases Regional
ISSN:	0143-4004, 1532-3102, 1532-3102
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Shrnutí:	Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE activity/mg protein at 8-9 sites between the cord insertion and the periphery in 12 term placentae from normotensive, vaginally-delivered women. ACE increased from insertion to the periphery (P = 0.015); median ACE for each placenta was positively correlated with placental weight (P < 0.05) and placental:birthweight ratio (P < 0.02). We speculate that this may be related to fetal programming since placental:birthweight ratio is related to long-term health.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0143-4004 1532-3102 1532-3102
DOI:	10.1016/j.placenta.2011.07.085