Regional variation in angiotensin converting enzyme activity in the human placenta

Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE activity/mg protein at 8-9 sites between the cord i...

Full description

Saved in:
Bibliographic Details
Published in:Placenta (Eastbourne) Vol. 32; no. 11; pp. 906 - 908
Main Authors: Brameld, J.M., Hold, R., Broughton Pipkin, F.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.11.2011
Elsevier
Subjects:
Angiotensin converting enzyme
Angiotensin II
Biological and medical sciences
Birth Weight - physiology
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development - physiology
Enzyme Activation
Female
Fundamental and applied biological sciences. Psychology
Gestational Age
human
Humans
Hypertension, Pregnancy-Induced - metabolism
Infant, Newborn
Internal Medicine
Obesity - complications
Obesity - metabolism
Obesity - pathology
Obstetrics and Gynecology
Organ Size
Peptidyl-Dipeptidase A - metabolism
Peptidyl-Dipeptidase A - physiology
Placenta
Placenta - anatomy & histology
Placenta - enzymology
Placenta - metabolism
Placenta - pathology
placenta:birthweight ratio
Placental size
Pregnancy
Pregnancy Complications - metabolism
Pregnancy Complications - pathology
Sampling site
Tissue Distribution
Umbilical Cord - anatomy & histology
Umbilical Cord - pathology
Sampling site
Placenta
Angiotensin converting enzyme
Placental size
placenta:birthweight ratio
Angiotensin II
human
Human
Peptidases
Vertebrata
Mammalia
Fetal membrane
Enzyme
Peptidyl-dipeptidase A
Hydrolases
Peptidyl-dipeptidases
Regional
ISSN:0143-4004, 1532-3102, 1532-3102
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE activity/mg protein at 8-9 sites between the cord insertion and the periphery in 12 term placentae from normotensive, vaginally-delivered women. ACE increased from insertion to the periphery (P = 0.015); median ACE for each placenta was positively correlated with placental weight (P < 0.05) and placental:birthweight ratio (P < 0.02). We speculate that this may be related to fetal programming since placental:birthweight ratio is related to long-term health.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2011.07.085