Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Ataxia telangiectasia mutated （ATM） kinase plays an essential role in the maintenance of genomic stability. ATM-deficient （ATM-/-） mice exhibit hematopoietic stem cell （HSC） dysfunction and a high incidence of lym- phoma. Gadd45a controls cell cycle arrest, apoptosis and DNA repair, and is involved...

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Bibliographic Details
Published in:	Protein & cell Vol. 5; no. 1; pp. 80 - 89
Main Authors:	Chen, Yulin, Yang, Runan, Guo, Peng, Ju, Zhenyu
Format:	Journal Article
Language:	English
Published:	Beijing Higher Education Press 2014 Springer Nature B.V
Subjects:	Animals Ataxia Telangiectasia Mutated Proteins - genetics ATM a蛋白 B-Lymphocytes - pathology Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Proteins - genetics Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 - metabolism Developmental Biology DNA Damage DNA损伤 Gadd45 Gadd45a Hematopoietic Stem Cell Transplantation hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Human Genetics Leukemia - genetics Leukemia - pathology Life Sciences Lymphoma - genetics Lymphoma - pathology Mice, Knockout Neoplasm Metastasis Nuclear Proteins - genetics Protein Science Research Article Stem Cells T-Lymphocytes - pathology Tumor Suppressor Protein p53 - metabolism 功能障碍小鼠缺陷造血干细胞 Gadd45a ATM hematopoietic stem cells DNA damage
ISSN:	1674-800X, 1674-8018, 1674-8018
Online Access:	Get full text
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