Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma
Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic m...
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| Veröffentlicht in: | Journal of cellular and molecular medicine Jg. 25; H. 4; S. 2279 - 2284 |
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| Abstract | Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high‐fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis, qRT‐PCR, and ELISA. The percentage of Tregs was measured by flow cytometry. Obese asthmatic mice displayed more severe airway inflammation and more significant changes in inflammatory cytokines. Metformin reversed the obese situation and alleviated the airway inflammation and remodelling with increased Tregs and related transcript factors. The anti‐inflammatory function of metformin may be mediated by increasing Tregs. |
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| AbstractList | Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high‐fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis, qRT‐PCR, and ELISA. The percentage of Tregs was measured by flow cytometry. Obese asthmatic mice displayed more severe airway inflammation and more significant changes in inflammatory cytokines. Metformin reversed the obese situation and alleviated the airway inflammation and remodelling with increased Tregs and related transcript factors. The anti‐inflammatory function of metformin may be mediated by increasing Tregs. Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high-fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis, qRT-PCR, and ELISA. The percentage of Tregs was measured by flow cytometry. Obese asthmatic mice displayed more severe airway inflammation and more significant changes in inflammatory cytokines. Metformin reversed the obese situation and alleviated the airway inflammation and remodelling with increased Tregs and related transcript factors. The anti-inflammatory function of metformin may be mediated by increasing Tregs.Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high-fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis, qRT-PCR, and ELISA. The percentage of Tregs was measured by flow cytometry. Obese asthmatic mice displayed more severe airway inflammation and more significant changes in inflammatory cytokines. Metformin reversed the obese situation and alleviated the airway inflammation and remodelling with increased Tregs and related transcript factors. The anti-inflammatory function of metformin may be mediated by increasing Tregs. |
| Author | Wang, Qiujie Guo, Yimin Chen, Ming Jiang, Shanping Shi, Jianting Hong, Luna Yuan, Xiaoqing Liu, Shanying |
| AuthorAffiliation | 4 Research Center of Medicine Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China 1 Department of Respiratory Medicine Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China 2 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China 3 Institute of Pulmonary Diseases Sun Yat‐sen University Guangzhou China 5 Breast Tumor Center Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China |
| AuthorAffiliation_xml | – name: 3 Institute of Pulmonary Diseases Sun Yat‐sen University Guangzhou China – name: 5 Breast Tumor Center Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China – name: 2 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China – name: 1 Department of Respiratory Medicine Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China – name: 4 Research Center of Medicine Sun Yat‐sen University Second University Hospital Sun Yat‐sen University Guangzhou China |
| Author_xml | – sequence: 1 givenname: Yimin surname: Guo fullname: Guo, Yimin organization: Sun Yat‐sen University – sequence: 2 givenname: Jianting surname: Shi fullname: Shi, Jianting organization: Sun Yat‐sen University – sequence: 3 givenname: Qiujie orcidid: 0000-0003-4942-8166 surname: Wang fullname: Wang, Qiujie organization: Sun Yat‐sen University – sequence: 4 givenname: Luna surname: Hong fullname: Hong, Luna organization: Sun Yat‐sen University – sequence: 5 givenname: Ming surname: Chen fullname: Chen, Ming organization: Sun Yat‐sen University – sequence: 6 givenname: Shanying surname: Liu fullname: Liu, Shanying organization: Sun Yat‐sen University – sequence: 7 givenname: Xiaoqing surname: Yuan fullname: Yuan, Xiaoqing email: yuanxq@csu.edu.cn organization: Sun Yat‐Sen University – sequence: 8 givenname: Shanping surname: Jiang fullname: Jiang, Shanping email: jiangshp@mail.sysu.edu.cn organization: Sun Yat‐sen University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33421348$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1182/blood-2014-04-568451 10.4049/jimmunol.178.3.1433 10.1590/S0074-02762005000900024 10.1084/jem.20051506 10.1089/104303402760293547 10.1182/blood-2009-05-220004 10.4049/jimmunol.149.7.2378 10.1371/journal.pone.0076786 10.1016/j.fct.2010.12.004 10.1111/resp.12818 10.1016/j.jaci.2011.03.036 10.1016/j.ajpath.2020.07.012 10.4049/jimmunol.1401612 |
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| Copyright | 2021 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | Tregs Obese asthma Metformin |
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| License | Attribution 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Funding information This study was supported by National Nature Science Foundation of China (No.81670022, 81803636 and 8170010835), Nature Science Foundation of Guangdong Province (No.2017A030313822 and 2018A0303130329), Guangzhou Science and Technology Program Key Project (No.201704020123 and 202008040003) and Guangdong Key Technology R & D Program for Controlling 2019 n‐Cov (No.2020B111105001). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Yimin Guo and Jianting Shi contributed equally to this manuscript. |
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| References | 2011; 127 2007; 178 2015; 194 2020; 190 2005; 100 2005; 202 2002; 13 2016; 21 1992; 149 2013; 8 2011; 49 2009; 114 2014; 124 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_12_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_16_1 |
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| SubjectTerms | Allergens Animals Anti-Inflammatory Agents - pharmacology Antidiabetics Asthma Asthma - drug therapy Asthma - immunology Asthma - pathology Binding sites Body weight Body Weight - drug effects Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology CD4 Lymphocyte Count Cholesterol Corticosteroids Cytokines Diet, High-Fat Disease Models, Animal Enzyme-linked immunosorbent assay Flow cytometry High fat diet Humans Hypoglycemic Agents - pharmacology Immunoregulation Inflammation Interleukin-4 - antagonists & inhibitors Interleukin-4 - immunology Interleukin-4 - metabolism Lipoproteins Lung - drug effects Lung - immunology Lung - pathology Lymphocytes T Metformin Metformin - pharmacology Mice Morbidity Obese asthma Obesity Obesity - drug therapy Obesity - immunology Obesity - pathology Ovalbumin Ovalbumin - administration & dosage Respiratory tract Respiratory tract diseases Short Communication Short Communications Software Spleen Spleen - drug effects Spleen - immunology Spleen - pathology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Transcription Transcription factors Tregs Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism |
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| Title | Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma |
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