Oxidative cell death in cancer: mechanisms and therapeutic opportunities

Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse cellular functions, including cell signaling and immune responses. However, a dist...

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Veröffentlicht in:Cell death & disease Jg. 15; H. 8; S. 556 - 20
Hauptverfasser: An, Xiaoqin, Yu, Wenfeng, Liu, Jinbao, Tang, Daolin, Yang, Li, Chen, Xin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.08.2024
Springer Nature B.V
Nature Publishing Group
Schlagworte:
631/67
631/80/82
Animals
Antibodies
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer
Cancer therapies
Cell Biology
Cell Culture
Cell Death
Cell signaling
Ferroptosis
Ferroptosis - drug effects
Humans
Immune response
Immunology
Life Sciences
Lipid metabolism
Necroptosis
Neoplasms - metabolism
Neoplasms - pathology
Oxidation-Reduction
Oxidative Stress
Pyroptosis
Reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Review Article
Signal Transduction
Tumorigenesis
ISSN:2041-4889, 2041-4889
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Zusammenfassung:Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse cellular functions, including cell signaling and immune responses. However, a disturbance in the balance between ROS production and cellular antioxidant defenses can lead to an excessive ROS buildup, causing oxidative stress. This stress damages essential cellular components, including lipids, proteins, and DNA, potentially culminating in oxidative cell death. This form of cell death can take various forms, such as ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, and oxeiptosis, each displaying distinct genetic, biochemical, and signaling characteristics. The investigation of oxidative cell death holds promise for the development of pharmacological agents that are used to prevent tumorigenesis or treat established cancer. Specifically, targeting key antioxidant proteins, such as SLC7A11, GCLC, GPX4, TXN, and TXNRD, represents an emerging approach for inducing oxidative cell death in cancer cells. This review provides a comprehensive summary of recent progress, opportunities, and challenges in targeting oxidative cell death for cancer therapy.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-024-06939-5