Oxidative cell death in cancer: mechanisms and therapeutic opportunities

Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse cellular functions, including cell signaling and immune responses. However, a dist...

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Vydáno v:	Cell death & disease Ročník 15; číslo 8; s. 556 - 20
Hlavní autoři:	An, Xiaoqin, Yu, Wenfeng, Liu, Jinbao, Tang, Daolin, Yang, Li, Chen, Xin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.08.2024 Springer Nature B.V Nature Publishing Group
Témata:	631/67 631/80/82 Animals Antibodies Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cancer therapies Cell Biology Cell Culture Cell Death Cell signaling Ferroptosis Ferroptosis - drug effects Humans Immune response Immunology Life Sciences Lipid metabolism Necroptosis Neoplasms - metabolism Neoplasms - pathology Oxidation-Reduction Oxidative Stress Pyroptosis Reactive oxygen species Reactive Oxygen Species - metabolism Review Review Article Signal Transduction Tumorigenesis
ISSN:	2041-4889, 2041-4889
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse cellular functions, including cell signaling and immune responses. However, a disturbance in the balance between ROS production and cellular antioxidant defenses can lead to an excessive ROS buildup, causing oxidative stress. This stress damages essential cellular components, including lipids, proteins, and DNA, potentially culminating in oxidative cell death. This form of cell death can take various forms, such as ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, and oxeiptosis, each displaying distinct genetic, biochemical, and signaling characteristics. The investigation of oxidative cell death holds promise for the development of pharmacological agents that are used to prevent tumorigenesis or treat established cancer. Specifically, targeting key antioxidant proteins, such as SLC7A11, GCLC, GPX4, TXN, and TXNRD, represents an emerging approach for inducing oxidative cell death in cancer cells. This review provides a comprehensive summary of recent progress, opportunities, and challenges in targeting oxidative cell death for cancer therapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-024-06939-5