Characteristics of SARS-CoV-2 and COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Rev...

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Vydáno v:	Nature reviews. Microbiology Ročník 19; číslo 3; s. 141 - 154
Hlavní autoři:	Hu, Ben, Guo, Hua, Zhou, Peng, Shi, Zheng-Li
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.03.2021 Nature Publishing Group
Témata:	631/326/596 631/326/596/4130 692/699/255/2514 692/700/478 Age Factors Animal models Animals Antiviral drugs Biomedical and Life Sciences Coronaviridae Coronavirus - classification Coronavirus - genetics Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - pathology COVID-19 - virology Epidemiology Health services Host-virus relationships Humans Infectious Diseases Life Sciences Medical Microbiology Microbiology Observations Pandemics Parasitology Pathogenesis Phylogeny Public safety Respiratory diseases Review Review Article SARS-CoV-2 - classification SARS-CoV-2 - genetics SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Viral diseases Virology Virulence (Microbiology) Virus research Viruses Wildlife Zoonoses China
ISSN:	1740-1526, 1740-1534, 1740-1534
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Shrnutí:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail. In this Review, Shi and colleagues summarize the exceptional amount of research that has characterized acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) since this virus has swept around the globe. They discuss what we know so far about the emergence and virology of SARS-CoV-2 and the pathogenesis and treatment of COVID-19.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1740-1526 1740-1534 1740-1534
DOI:	10.1038/s41579-020-00459-7