Characteristics of SARS-CoV-2 and COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named 'coronavirus disease 2019' (COVID-19), which threatens human health and public safety. I...

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Bibliographic Details
Published in:Nature reviews. Microbiology Vol. 19; no. 3; pp. 141 - 154
Main Authors: Hu, Ben, Guo, Hua, Zhou, Peng, Shi, Zheng-Li
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.03.2021
Subjects:
Age Factors
Animal models
Animals
Antiviral drugs
Coronaviridae
Coronavirus - classification
Coronavirus - genetics
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - pathology
COVID-19 - virology
Epidemiology
Health services
Humans
Pandemics
Pathogenesis
Phylogeny
Public safety
Respiratory diseases
SARS-CoV-2 - classification
SARS-CoV-2 - genetics
SARS-CoV-2 - physiology
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Virology
Viruses
Wildlife
Zoonoses
ISSN:1740-1526, 1740-1534, 1740-1534
Online Access:Get full text
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named 'coronavirus disease 2019' (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-020-00459-7