Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations

As the continent of origin for our species, Africa harbours the highest levels of diversity anywhere on Earth. However, many regions of Africa remain under-sampled genetically. Here we present 350 whole genomes from Angola and Mozambique belonging to ten Bantu ethnolinguistic groups, enabling the co...

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Vydané v:	Nature communications Ročník 14; číslo 1; s. 7967 - 14
Hlavní autori:	Tallman, Sam, Sungo, Maria das Dores, Saranga, Sílvio, Beleza, Sandra
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 02.12.2023 Nature Publishing Group Nature Portfolio
Predmet:	45/23 631/181/457/649 631/208/457/649 African Americans African history Angola Archaeology Bantu languages Black or African American Black People - genetics Demographics Demography Ethnolinguistic groups Ethnolinguistics Gene sequencing Genetic Variation Genetics Genetics, Population Genomes Genomics Health care Health services Humanities and Social Sciences Humans Linguistics Mozambique multidisciplinary Polymorphism, Single Nucleotide Population structure Science Science (multidisciplinary) Sequences Single-nucleotide polymorphism Slave trade Angola Mozambique Africa
ISSN:	2041-1723, 2041-1723
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Shrnutí:	As the continent of origin for our species, Africa harbours the highest levels of diversity anywhere on Earth. However, many regions of Africa remain under-sampled genetically. Here we present 350 whole genomes from Angola and Mozambique belonging to ten Bantu ethnolinguistic groups, enabling the construction of a reference variation catalogue including 2.9 million novel SNPs. We investigate the emergence of Bantu speaker population structure, admixture involving migrations across sub-Saharan Africa and model the demographic histories of Angolan and Mozambican Bantu speakers. Our results bring together concordant views from genomics, archaeology, and linguistics to paint an updated view of the complexity of the Bantu Expansion. Moreover, we generate reference panels that better represents the diversity of African populations involved in the trans-Atlantic slave trade, improving imputation accuracy in African Americans and Brazilians. We anticipate that our collection of genomes will form the foundation for future African genomic healthcare initiatives. African human genome variation remains under-sampled. Here, the authors present a collection of 350 whole genome sequences from Angola and Mozambique and model the timing and extent of significant demographic events in African history.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-023-43717-x