Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations

As the continent of origin for our species, Africa harbours the highest levels of diversity anywhere on Earth. However, many regions of Africa remain under-sampled genetically. Here we present 350 whole genomes from Angola and Mozambique belonging to ten Bantu ethnolinguistic groups, enabling the co...

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Bibliographic Details
Published in:Nature communications Vol. 14; no. 1; pp. 7967 - 14
Main Authors: Tallman, Sam, Sungo, Maria das Dores, Saranga, Sílvio, Beleza, Sandra
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 02.12.2023
Nature Publishing Group
Nature Portfolio
Subjects:
45/23
631/181/457/649
631/208/457/649
African Americans
African history
Angola
Archaeology
Bantu languages
Black or African American
Black People - genetics
Demographics
Demography
Ethnolinguistic groups
Ethnolinguistics
Gene sequencing
Genetic Variation
Genetics
Genetics, Population
Genomes
Genomics
Health care
Health services
Humanities and Social Sciences
Humans
Linguistics
Mozambique
multidisciplinary
Polymorphism, Single Nucleotide
Population structure
Science
Science (multidisciplinary)
Sequences
Single-nucleotide polymorphism
Slave trade
Angola
Mozambique
Africa
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:As the continent of origin for our species, Africa harbours the highest levels of diversity anywhere on Earth. However, many regions of Africa remain under-sampled genetically. Here we present 350 whole genomes from Angola and Mozambique belonging to ten Bantu ethnolinguistic groups, enabling the construction of a reference variation catalogue including 2.9 million novel SNPs. We investigate the emergence of Bantu speaker population structure, admixture involving migrations across sub-Saharan Africa and model the demographic histories of Angolan and Mozambican Bantu speakers. Our results bring together concordant views from genomics, archaeology, and linguistics to paint an updated view of the complexity of the Bantu Expansion. Moreover, we generate reference panels that better represents the diversity of African populations involved in the trans-Atlantic slave trade, improving imputation accuracy in African Americans and Brazilians. We anticipate that our collection of genomes will form the foundation for future African genomic healthcare initiatives. African human genome variation remains under-sampled. Here, the authors present a collection of 350 whole genome sequences from Angola and Mozambique and model the timing and extent of significant demographic events in African history.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-43717-x